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Fluctuation of Spuriously Elevated Troponin I: A Case Report
Serum troponin is a useful laboratory study for the diagnosis of acute myocardial infarction. However, elevations can also be seen in a variety of other diseases processes. Falsely positive troponin values caused by interference with current troponin assays have been reported. We report a unique cas...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010026/ https://www.ncbi.nlm.nih.gov/pubmed/24804120 http://dx.doi.org/10.1155/2012/585879 |
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author | Ghali, Sam Lewis, Keith Kazan, Viviane Altorok, Neezam Taji, Jamil Taleb, Mohammad Lanka, Kiranmayee Assaly, Ragheb |
author_facet | Ghali, Sam Lewis, Keith Kazan, Viviane Altorok, Neezam Taji, Jamil Taleb, Mohammad Lanka, Kiranmayee Assaly, Ragheb |
author_sort | Ghali, Sam |
collection | PubMed |
description | Serum troponin is a useful laboratory study for the diagnosis of acute myocardial infarction. However, elevations can also be seen in a variety of other diseases processes. Falsely positive troponin values caused by interference with current troponin assays have been reported. We report a unique case that demonstrates the fluctuation of falsely elevated troponin correlating with hemoglobin, serving as a marker of heterophile antibody levels. A 74-year-old gentleman presented to our Emergency Department with a several-day history of increasing shortness of breath associated with a new-onset chest pain and a troponin I level of 77.28 ng/mL. Throughout his stay, fluctuations in measured troponin levels correlated strongly with fluctuations in hemoglobin levels. Several investigations confirmed false elevated troponin levels secondary to heterophile antibody interference. We conclude that hemoglobin trending in our patient represented a surrogate measure of his heterophile antibody titers with time and that fluctuations in these levels correlated with respective fluctuations in the falsely elevated troponin levels. |
format | Online Article Text |
id | pubmed-4010026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40100262014-05-06 Fluctuation of Spuriously Elevated Troponin I: A Case Report Ghali, Sam Lewis, Keith Kazan, Viviane Altorok, Neezam Taji, Jamil Taleb, Mohammad Lanka, Kiranmayee Assaly, Ragheb Case Rep Crit Care Case Report Serum troponin is a useful laboratory study for the diagnosis of acute myocardial infarction. However, elevations can also be seen in a variety of other diseases processes. Falsely positive troponin values caused by interference with current troponin assays have been reported. We report a unique case that demonstrates the fluctuation of falsely elevated troponin correlating with hemoglobin, serving as a marker of heterophile antibody levels. A 74-year-old gentleman presented to our Emergency Department with a several-day history of increasing shortness of breath associated with a new-onset chest pain and a troponin I level of 77.28 ng/mL. Throughout his stay, fluctuations in measured troponin levels correlated strongly with fluctuations in hemoglobin levels. Several investigations confirmed false elevated troponin levels secondary to heterophile antibody interference. We conclude that hemoglobin trending in our patient represented a surrogate measure of his heterophile antibody titers with time and that fluctuations in these levels correlated with respective fluctuations in the falsely elevated troponin levels. Hindawi Publishing Corporation 2012 2012-03-25 /pmc/articles/PMC4010026/ /pubmed/24804120 http://dx.doi.org/10.1155/2012/585879 Text en Copyright © 2012 Sam Ghali et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Ghali, Sam Lewis, Keith Kazan, Viviane Altorok, Neezam Taji, Jamil Taleb, Mohammad Lanka, Kiranmayee Assaly, Ragheb Fluctuation of Spuriously Elevated Troponin I: A Case Report |
title | Fluctuation of Spuriously Elevated Troponin I: A Case Report |
title_full | Fluctuation of Spuriously Elevated Troponin I: A Case Report |
title_fullStr | Fluctuation of Spuriously Elevated Troponin I: A Case Report |
title_full_unstemmed | Fluctuation of Spuriously Elevated Troponin I: A Case Report |
title_short | Fluctuation of Spuriously Elevated Troponin I: A Case Report |
title_sort | fluctuation of spuriously elevated troponin i: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010026/ https://www.ncbi.nlm.nih.gov/pubmed/24804120 http://dx.doi.org/10.1155/2012/585879 |
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