Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature

Calcium channel antagonists (CCAs) are commonly involved in drug overdoses. Standard approaches to the management of CCA overdoses, including fluid resuscitation, gut decontamination, administration of calcium, glucagon, and atropine, as well as supportive care, are often ineffective. We report on t...

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Autores principales: Shah, Shiwan K., Goswami, Sanjeev Kumar, Babu, Rajesh V., Sharma, Gulshan, Duarte, Alexander G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010055/
https://www.ncbi.nlm.nih.gov/pubmed/24826345
http://dx.doi.org/10.1155/2012/927040
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author Shah, Shiwan K.
Goswami, Sanjeev Kumar
Babu, Rajesh V.
Sharma, Gulshan
Duarte, Alexander G.
author_facet Shah, Shiwan K.
Goswami, Sanjeev Kumar
Babu, Rajesh V.
Sharma, Gulshan
Duarte, Alexander G.
author_sort Shah, Shiwan K.
collection PubMed
description Calcium channel antagonists (CCAs) are commonly involved in drug overdoses. Standard approaches to the management of CCA overdoses, including fluid resuscitation, gut decontamination, administration of calcium, glucagon, and atropine, as well as supportive care, are often ineffective. We report on two patients who improved after addition of hyperinsulinemia-euglycemia (HIE) therapy. We conclude with a literature review on hyperinsulinemia-euglycemia therapy with an exploration of the physiology behind its potential use.
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spelling pubmed-40100552014-05-13 Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature Shah, Shiwan K. Goswami, Sanjeev Kumar Babu, Rajesh V. Sharma, Gulshan Duarte, Alexander G. Case Rep Crit Care Case Report Calcium channel antagonists (CCAs) are commonly involved in drug overdoses. Standard approaches to the management of CCA overdoses, including fluid resuscitation, gut decontamination, administration of calcium, glucagon, and atropine, as well as supportive care, are often ineffective. We report on two patients who improved after addition of hyperinsulinemia-euglycemia (HIE) therapy. We conclude with a literature review on hyperinsulinemia-euglycemia therapy with an exploration of the physiology behind its potential use. Hindawi Publishing Corporation 2012 2012-02-14 /pmc/articles/PMC4010055/ /pubmed/24826345 http://dx.doi.org/10.1155/2012/927040 Text en Copyright © 2012 Shiwan K. Shah et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Shah, Shiwan K.
Goswami, Sanjeev Kumar
Babu, Rajesh V.
Sharma, Gulshan
Duarte, Alexander G.
Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature
title Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature
title_full Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature
title_fullStr Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature
title_full_unstemmed Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature
title_short Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature
title_sort management of calcium channel antagonist overdose with hyperinsulinemia-euglycemia therapy: case series and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010055/
https://www.ncbi.nlm.nih.gov/pubmed/24826345
http://dx.doi.org/10.1155/2012/927040
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