Direct Evidence for Pitavastatin Induced Chromatin Structure Change in the KLF4 Gene in Endothelial Cells

Statins exert atheroprotective effects through the induction of specific transcriptional factors in multiple organs. In endothelial cells, statin-dependent atheroprotective gene up-regulation is mediated by Kruppel-like factor (KLF) family transcription factors. To dissect the mechanism of gene regu...

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Detalles Bibliográficos
Autores principales: Maejima, Takashi, Inoue, Tsuyoshi, Kanki, Yasuharu, Kohro, Takahide, Li, Guoliang, Ohta, Yoshihiro, Kimura, Hiroshi, Kobayashi, Mika, Taguchi, Akashi, Tsutsumi, Shuichi, Iwanari, Hiroko, Yamamoto, Shogo, Aruga, Hirofumi, Dong, Shoulian, Stevens, Junko F., Poh, Huay Mei, Yamamoto, Kazuki, Kawamura, Takeshi, Mimura, Imari, Suehiro, Jun-ichi, Sugiyama, Akira, Kaneki, Kiyomi, Shibata, Haruki, Yoshinaka, Yasunobu, Doi, Takeshi, Asanuma, Akimune, Tanabe, Sohei, Tanaka, Toshiya, Minami, Takashi, Hamakubo, Takao, Sakai, Juro, Nozaki, Naohito, Aburatani, Hiroyuki, Nangaku, Masaomi, Ruan, Xiaoan, Tanabe, Hideyuki, Ruan, Yijun, Ihara, Sigeo, Endo, Akira, Kodama, Tatsuhiko, Wada, Youichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010393/
https://www.ncbi.nlm.nih.gov/pubmed/24797675
http://dx.doi.org/10.1371/journal.pone.0096005

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