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Expression of Neuron-Specific Enolase in Multiple Myeloma and Implications for Clinical Diagnosis and Treatment

OBJECTIVE: To determine the expression of neuron-specific enolase (NSE) in patients with multiple myeloma (MM) and to evaluate its clinical value as a tumor marker and, an indicator of disease progression and treatment efficacy. METHODS: Using electrochemiluminescence immunoassay (ECLIA), we measure...

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Autores principales: Yang, Haiping, Mi, Ruihua, Wang, Qian, Wei, Xudong, Yin, Qingsong, Chen, Lin, Zhu, Xinghu, Song, Yongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010394/
https://www.ncbi.nlm.nih.gov/pubmed/24796851
http://dx.doi.org/10.1371/journal.pone.0094304
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author Yang, Haiping
Mi, Ruihua
Wang, Qian
Wei, Xudong
Yin, Qingsong
Chen, Lin
Zhu, Xinghu
Song, Yongping
author_facet Yang, Haiping
Mi, Ruihua
Wang, Qian
Wei, Xudong
Yin, Qingsong
Chen, Lin
Zhu, Xinghu
Song, Yongping
author_sort Yang, Haiping
collection PubMed
description OBJECTIVE: To determine the expression of neuron-specific enolase (NSE) in patients with multiple myeloma (MM) and to evaluate its clinical value as a tumor marker and, an indicator of disease progression and treatment efficacy. METHODS: Using electrochemiluminescence immunoassay (ECLIA), we measured the serum levels of NSE in 47 healthy subjects (control group), 25 patients with small cell lung cancer (lung cancer group), and 52 patients with MM (MM group). For the MM group, serum NSE levels were measured and other disease indicators and related symptoms were monitored before and after chemotherapy. The relationship between NSE expression and other MM-related factors was analyzed. In addition, immunohistochemical staining was performed on bone marrow biopsy specimens from patients with MM. RESULTS: In the control group, serum NSE levels were within the normal range as previously reported, while the lung cancer group and the untreated MM group exhibited NSE levels that were significantly higher relative to the control group (P<0.05). The difference in NSE expression between the lung cancer group and untreated MM group was statistically significant (P<0.05). NSE levels were significantly decreased in MM patients after chemotherapy and were positively correlated with an MM disease index [beta-2 microglobulin (β(2)-MG)]. Changes in NSE were not related to the response rate to chemotherapy but rather were correlated with progression-free survival. CONCLUSIONS: Patients with MM may have increased serum NSE levels, and changes in NSE may provide insight into treatment efficacy of chemotherapy and disease progression. Perhaps NSE expression is a viable biomarker for MM and can be a useful reference for the design and adjustment of clinical MM treatment programs.
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spelling pubmed-40103942014-05-09 Expression of Neuron-Specific Enolase in Multiple Myeloma and Implications for Clinical Diagnosis and Treatment Yang, Haiping Mi, Ruihua Wang, Qian Wei, Xudong Yin, Qingsong Chen, Lin Zhu, Xinghu Song, Yongping PLoS One Research Article OBJECTIVE: To determine the expression of neuron-specific enolase (NSE) in patients with multiple myeloma (MM) and to evaluate its clinical value as a tumor marker and, an indicator of disease progression and treatment efficacy. METHODS: Using electrochemiluminescence immunoassay (ECLIA), we measured the serum levels of NSE in 47 healthy subjects (control group), 25 patients with small cell lung cancer (lung cancer group), and 52 patients with MM (MM group). For the MM group, serum NSE levels were measured and other disease indicators and related symptoms were monitored before and after chemotherapy. The relationship between NSE expression and other MM-related factors was analyzed. In addition, immunohistochemical staining was performed on bone marrow biopsy specimens from patients with MM. RESULTS: In the control group, serum NSE levels were within the normal range as previously reported, while the lung cancer group and the untreated MM group exhibited NSE levels that were significantly higher relative to the control group (P<0.05). The difference in NSE expression between the lung cancer group and untreated MM group was statistically significant (P<0.05). NSE levels were significantly decreased in MM patients after chemotherapy and were positively correlated with an MM disease index [beta-2 microglobulin (β(2)-MG)]. Changes in NSE were not related to the response rate to chemotherapy but rather were correlated with progression-free survival. CONCLUSIONS: Patients with MM may have increased serum NSE levels, and changes in NSE may provide insight into treatment efficacy of chemotherapy and disease progression. Perhaps NSE expression is a viable biomarker for MM and can be a useful reference for the design and adjustment of clinical MM treatment programs. Public Library of Science 2014-05-05 /pmc/articles/PMC4010394/ /pubmed/24796851 http://dx.doi.org/10.1371/journal.pone.0094304 Text en © 2014 Yang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yang, Haiping
Mi, Ruihua
Wang, Qian
Wei, Xudong
Yin, Qingsong
Chen, Lin
Zhu, Xinghu
Song, Yongping
Expression of Neuron-Specific Enolase in Multiple Myeloma and Implications for Clinical Diagnosis and Treatment
title Expression of Neuron-Specific Enolase in Multiple Myeloma and Implications for Clinical Diagnosis and Treatment
title_full Expression of Neuron-Specific Enolase in Multiple Myeloma and Implications for Clinical Diagnosis and Treatment
title_fullStr Expression of Neuron-Specific Enolase in Multiple Myeloma and Implications for Clinical Diagnosis and Treatment
title_full_unstemmed Expression of Neuron-Specific Enolase in Multiple Myeloma and Implications for Clinical Diagnosis and Treatment
title_short Expression of Neuron-Specific Enolase in Multiple Myeloma and Implications for Clinical Diagnosis and Treatment
title_sort expression of neuron-specific enolase in multiple myeloma and implications for clinical diagnosis and treatment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010394/
https://www.ncbi.nlm.nih.gov/pubmed/24796851
http://dx.doi.org/10.1371/journal.pone.0094304
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