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Human Papillomavirus 16 Oncoprotein E7 Stimulates UBF1-Mediated rDNA Gene Transcription, Inhibiting a p53-Independent Activity of p14(ARF)

High-risk human papillomavirus oncoproteins E6 and E7 play a major role in HPV-related cancers. One of the main functions of E7 is the degradation of pRb, while E6 promotes the degradation of p53, inactivating the p14(ARF)-p53 pathway. pRb and p14(ARF) can repress ribosomal DNA (rDNA) transcription...

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Detalles Bibliográficos
Autores principales:	Dichamp, Isabelle, Séité, Paule, Agius, Gérard, Barbarin, Alice, Beby-Defaux, Agnès
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010441/ https://www.ncbi.nlm.nih.gov/pubmed/24798431 http://dx.doi.org/10.1371/journal.pone.0096136

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