Hyper-Activation of Notch3 Amplifies the Proliferative Potential of Rhabdomyosarcoma Cells

Rhabdomyosarcoma (RMS) is a pediatric myogenic-derived soft tissue sarcoma that includes two major histopathological subtypes: embryonal and alveolar. The majority of alveolar RMS expresses PAX3-FOXO1 fusion oncoprotein, associated with the worst prognosis. RMS cells show myogenic markers expression...

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Detalles Bibliográficos
Autores principales: De Salvo, Maria, Raimondi, Lavinia, Vella, Serena, Adesso, Laura, Ciarapica, Roberta, Verginelli, Federica, Pannuti, Antonio, Citti, Arianna, Boldrini, Renata, Milano, Giuseppe M., Cacchione, Antonella, Ferrari, Andrea, Collini, Paola, Rosolen, Angelo, Bisogno, Gianni, Alaggio, Rita, Inserra, Alessandro, Locatelli, Mattia, Stifani, Stefano, Screpanti, Isabella, Miele, Lucio, Locatelli, Franco, Rota, Rossella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010457/
https://www.ncbi.nlm.nih.gov/pubmed/24797362
http://dx.doi.org/10.1371/journal.pone.0096238

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