Evaluation of Influence of Single Nucleotide Polymorphisms in Cytochrome P450 2B6 on Substrate Recognition Using Computational Docking and Molecular Dynamics Simulation

In this study, we investigated the influence of single nucleotide polymorphisms on the conformation of mutated cytochrome P450 (CYP) 2B6 proteins using molecular dynamics (MD) simulation. Some of these mutations influence drug metabolism activities, leading to individual variations in drug efficacy...

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Detalles Bibliográficos
Autores principales: Kobayashi, Kana, Takahashi, Ohgi, Hiratsuka, Masahiro, Yamaotsu, Noriyuki, Hirono, Shuichi, Watanabe, Yurie, Oda, Akifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010486/
https://www.ncbi.nlm.nih.gov/pubmed/24796891
http://dx.doi.org/10.1371/journal.pone.0096789

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