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Detection of Early Age-Related Macular Degeneration Using Novel Functional Parameters of the Focal Cone Electroretinogram
The focal cone electroretinogram is a sensitive marker for macular disease, but have we unlocked its full potential? Typically assessment of waveform parameters is subjective and focuses on a small number of locations (e.g. the a-wave). This study evaluated the discriminatory and diagnostic potentia...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010489/ https://www.ncbi.nlm.nih.gov/pubmed/24796326 http://dx.doi.org/10.1371/journal.pone.0096742 |
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author | Wood, Ashley Margrain, Thomas Binns, Alison Mary |
author_facet | Wood, Ashley Margrain, Thomas Binns, Alison Mary |
author_sort | Wood, Ashley |
collection | PubMed |
description | The focal cone electroretinogram is a sensitive marker for macular disease, but have we unlocked its full potential? Typically assessment of waveform parameters is subjective and focuses on a small number of locations (e.g. the a-wave). This study evaluated the discriminatory and diagnostic potential of 4 conventional and 15 novel, objectively determined, parameters in patients with early Age-related Macular Degeneration. Focal cone electroretinograms were recorded in 54 participants with early Age-related Macular Degeneration (72.9±8.2 years) and 54 healthy controls (69±7.7 years). Conventional a and b wave amplitudes and implicit times were measured and compared to novel parameters derived from both the 1st and 2nd derivatives and the frequency-domain power spectrum of the electroretinogram.Statistically significant differences between groups were shown for all conventional parameters, the majority of 1st and 2nd derivative parameters and the power spectrum at 25 and 30 Hz. Receiver operating characteristics showed that both conventional and 1st and 2nd derivative implicit times had provided the best diagnostic potential. A regression model showed a small improvement over any individual parameter investigated. The non-conventional parameters enhanced the objective evaluation of the focal electroretinogram, especially when the amplitude was low. Furthermore, the novel parameters described here allow the implicit time of the electroretinogram to be probed at points other than the peaks of the a and b waves. Consequently these novel analysis techniques could prove valuable in future electrophysiological investigation, detection and monitoring of Age-related Macular Degeneration. |
format | Online Article Text |
id | pubmed-4010489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40104892014-05-09 Detection of Early Age-Related Macular Degeneration Using Novel Functional Parameters of the Focal Cone Electroretinogram Wood, Ashley Margrain, Thomas Binns, Alison Mary PLoS One Research Article The focal cone electroretinogram is a sensitive marker for macular disease, but have we unlocked its full potential? Typically assessment of waveform parameters is subjective and focuses on a small number of locations (e.g. the a-wave). This study evaluated the discriminatory and diagnostic potential of 4 conventional and 15 novel, objectively determined, parameters in patients with early Age-related Macular Degeneration. Focal cone electroretinograms were recorded in 54 participants with early Age-related Macular Degeneration (72.9±8.2 years) and 54 healthy controls (69±7.7 years). Conventional a and b wave amplitudes and implicit times were measured and compared to novel parameters derived from both the 1st and 2nd derivatives and the frequency-domain power spectrum of the electroretinogram.Statistically significant differences between groups were shown for all conventional parameters, the majority of 1st and 2nd derivative parameters and the power spectrum at 25 and 30 Hz. Receiver operating characteristics showed that both conventional and 1st and 2nd derivative implicit times had provided the best diagnostic potential. A regression model showed a small improvement over any individual parameter investigated. The non-conventional parameters enhanced the objective evaluation of the focal electroretinogram, especially when the amplitude was low. Furthermore, the novel parameters described here allow the implicit time of the electroretinogram to be probed at points other than the peaks of the a and b waves. Consequently these novel analysis techniques could prove valuable in future electrophysiological investigation, detection and monitoring of Age-related Macular Degeneration. Public Library of Science 2014-05-05 /pmc/articles/PMC4010489/ /pubmed/24796326 http://dx.doi.org/10.1371/journal.pone.0096742 Text en © 2014 Wood et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Wood, Ashley Margrain, Thomas Binns, Alison Mary Detection of Early Age-Related Macular Degeneration Using Novel Functional Parameters of the Focal Cone Electroretinogram |
title | Detection of Early Age-Related Macular Degeneration Using Novel Functional Parameters of the Focal Cone Electroretinogram |
title_full | Detection of Early Age-Related Macular Degeneration Using Novel Functional Parameters of the Focal Cone Electroretinogram |
title_fullStr | Detection of Early Age-Related Macular Degeneration Using Novel Functional Parameters of the Focal Cone Electroretinogram |
title_full_unstemmed | Detection of Early Age-Related Macular Degeneration Using Novel Functional Parameters of the Focal Cone Electroretinogram |
title_short | Detection of Early Age-Related Macular Degeneration Using Novel Functional Parameters of the Focal Cone Electroretinogram |
title_sort | detection of early age-related macular degeneration using novel functional parameters of the focal cone electroretinogram |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010489/ https://www.ncbi.nlm.nih.gov/pubmed/24796326 http://dx.doi.org/10.1371/journal.pone.0096742 |
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