Obesity and renal cancer: Role of adipokines in the tumor-immune system conflict

Epidemiological studies link obesity, as measured by increased body mass index (BMI) to the incidence of renal cell carcinoma (RCC) as well as to the cancer-related mortality of RCC patients. RCC is the third cancer most robustly associated with increased BMI. Understanding the role of the adipose t...

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Detalles Bibliográficos
Autores principales: Gati, Asma, Kouidhi, Soumaya, Marrakchi, Raja, El Gaaied, Amel, Kourda, Nadia, Derouiche, Amine, Chebil, Mohamed, Caignard, Anne, Perier, Aurélie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010540/
https://www.ncbi.nlm.nih.gov/pubmed/24804162
http://dx.doi.org/10.4161/onci.27810
Descripción
Sumario:Epidemiological studies link obesity, as measured by increased body mass index (BMI) to the incidence of renal cell carcinoma (RCC) as well as to the cancer-related mortality of RCC patients. RCC is the third cancer most robustly associated with increased BMI. Understanding the role of the adipose tissue in renal carcinogenesis is therefore of major importance for the development of novel paradigms of RCC prevention and treatment. Here, we discuss the current knowledge on the impact of obesity on the development and progression of RCC as well as the role of adipose tissue-derived hormones (adipokines) in the conflict between growing tumors and the immune system.

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