Obesity and renal cancer: Role of adipokines in the tumor-immune system conflict

Epidemiological studies link obesity, as measured by increased body mass index (BMI) to the incidence of renal cell carcinoma (RCC) as well as to the cancer-related mortality of RCC patients. RCC is the third cancer most robustly associated with increased BMI. Understanding the role of the adipose t...

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Autores principales: Gati, Asma, Kouidhi, Soumaya, Marrakchi, Raja, El Gaaied, Amel, Kourda, Nadia, Derouiche, Amine, Chebil, Mohamed, Caignard, Anne, Perier, Aurélie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010540/
https://www.ncbi.nlm.nih.gov/pubmed/24804162
http://dx.doi.org/10.4161/onci.27810
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author Gati, Asma
Kouidhi, Soumaya
Marrakchi, Raja
El Gaaied, Amel
Kourda, Nadia
Derouiche, Amine
Chebil, Mohamed
Caignard, Anne
Perier, Aurélie
author_facet Gati, Asma
Kouidhi, Soumaya
Marrakchi, Raja
El Gaaied, Amel
Kourda, Nadia
Derouiche, Amine
Chebil, Mohamed
Caignard, Anne
Perier, Aurélie
author_sort Gati, Asma
collection PubMed
description Epidemiological studies link obesity, as measured by increased body mass index (BMI) to the incidence of renal cell carcinoma (RCC) as well as to the cancer-related mortality of RCC patients. RCC is the third cancer most robustly associated with increased BMI. Understanding the role of the adipose tissue in renal carcinogenesis is therefore of major importance for the development of novel paradigms of RCC prevention and treatment. Here, we discuss the current knowledge on the impact of obesity on the development and progression of RCC as well as the role of adipose tissue-derived hormones (adipokines) in the conflict between growing tumors and the immune system.
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spelling pubmed-40105402015-01-16 Obesity and renal cancer: Role of adipokines in the tumor-immune system conflict Gati, Asma Kouidhi, Soumaya Marrakchi, Raja El Gaaied, Amel Kourda, Nadia Derouiche, Amine Chebil, Mohamed Caignard, Anne Perier, Aurélie Oncoimmunology Review Epidemiological studies link obesity, as measured by increased body mass index (BMI) to the incidence of renal cell carcinoma (RCC) as well as to the cancer-related mortality of RCC patients. RCC is the third cancer most robustly associated with increased BMI. Understanding the role of the adipose tissue in renal carcinogenesis is therefore of major importance for the development of novel paradigms of RCC prevention and treatment. Here, we discuss the current knowledge on the impact of obesity on the development and progression of RCC as well as the role of adipose tissue-derived hormones (adipokines) in the conflict between growing tumors and the immune system. Landes Bioscience 2014-01-16 /pmc/articles/PMC4010540/ /pubmed/24804162 http://dx.doi.org/10.4161/onci.27810 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Gati, Asma
Kouidhi, Soumaya
Marrakchi, Raja
El Gaaied, Amel
Kourda, Nadia
Derouiche, Amine
Chebil, Mohamed
Caignard, Anne
Perier, Aurélie
Obesity and renal cancer: Role of adipokines in the tumor-immune system conflict
title Obesity and renal cancer: Role of adipokines in the tumor-immune system conflict
title_full Obesity and renal cancer: Role of adipokines in the tumor-immune system conflict
title_fullStr Obesity and renal cancer: Role of adipokines in the tumor-immune system conflict
title_full_unstemmed Obesity and renal cancer: Role of adipokines in the tumor-immune system conflict
title_short Obesity and renal cancer: Role of adipokines in the tumor-immune system conflict
title_sort obesity and renal cancer: role of adipokines in the tumor-immune system conflict
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010540/
https://www.ncbi.nlm.nih.gov/pubmed/24804162
http://dx.doi.org/10.4161/onci.27810
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