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Leptin-stimulated K(ATP) channel trafficking: A new paradigm for β-cell stimulus-secretion coupling?
Insulin secretion from pancreatic β-cells is initiated by the closure of ATP-sensitive K(+) channels (K(ATP)) in response to high concentrations of glucose, and this action of glucose is counteracted by the hormone leptin, an adipokine that signals through the Ob-R(b) receptor to increase K(ATP) cha...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010576/ https://www.ncbi.nlm.nih.gov/pubmed/24213304 http://dx.doi.org/10.4161/isl.26958 |