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Sleep enhances inhibitory behavioral control in discrimination learning in rats

Sleep supports the consolidation of memory, and it has been proposed that this enhancing effect of sleep pertains in particular to memories which are encoded under control of prefrontal–hippocampal circuitry into an episodic memory system. Furthermore, repeated reactivation and transformation of suc...

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Autores principales: Borquez, Margarita, Born, Jan, Navarro, Victor, Betancourt, Ronald, Inostroza, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010722/
https://www.ncbi.nlm.nih.gov/pubmed/24322821
http://dx.doi.org/10.1007/s00221-013-3797-5
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author Borquez, Margarita
Born, Jan
Navarro, Victor
Betancourt, Ronald
Inostroza, Marion
author_facet Borquez, Margarita
Born, Jan
Navarro, Victor
Betancourt, Ronald
Inostroza, Marion
author_sort Borquez, Margarita
collection PubMed
description Sleep supports the consolidation of memory, and it has been proposed that this enhancing effect of sleep pertains in particular to memories which are encoded under control of prefrontal–hippocampal circuitry into an episodic memory system. Furthermore, repeated reactivation and transformation of such memories during sleep are thought to promote the de-contextualization of these memories. Here, we aimed to establish a behavioral model for the study of such sleep-dependent system consolidation in rats, using a go/nogo conditional discrimination learning task known to essentially depend on prefrontal–hippocampal function. Different groups of rats were trained to criterion on this task and, then, subjected to 80-min retention intervals filled with spontaneous morning sleep, sleep deprivation, or spontaneous evening wakefulness. In a subsequent test phase, the speed of relearning of the discrimination task was examined as indicator of memory, whereby rats were either tested in the same context as during training or in a different context. Sleep promoted relearning of the conditional discrimination task, and this effect was similar for testing memory in the same or different context (p < 0.001). Independent of sleep and wakefulness during the retention interval, animals showed faster relearning when tested in the same context as during learning, compared with testing in a different context (p < 0.001). The benefitting effect of sleep on discrimination learning was primarily due to an enhancing effect on response suppression during the nogo stimulus. We infer from these results that sleep enhances memory for inhibitory behavioral control in a generalized context-independent manner and thereby might eventually also contribute to the abstraction of schema-like representations.
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spelling pubmed-40107222014-05-07 Sleep enhances inhibitory behavioral control in discrimination learning in rats Borquez, Margarita Born, Jan Navarro, Victor Betancourt, Ronald Inostroza, Marion Exp Brain Res Research Article Sleep supports the consolidation of memory, and it has been proposed that this enhancing effect of sleep pertains in particular to memories which are encoded under control of prefrontal–hippocampal circuitry into an episodic memory system. Furthermore, repeated reactivation and transformation of such memories during sleep are thought to promote the de-contextualization of these memories. Here, we aimed to establish a behavioral model for the study of such sleep-dependent system consolidation in rats, using a go/nogo conditional discrimination learning task known to essentially depend on prefrontal–hippocampal function. Different groups of rats were trained to criterion on this task and, then, subjected to 80-min retention intervals filled with spontaneous morning sleep, sleep deprivation, or spontaneous evening wakefulness. In a subsequent test phase, the speed of relearning of the discrimination task was examined as indicator of memory, whereby rats were either tested in the same context as during training or in a different context. Sleep promoted relearning of the conditional discrimination task, and this effect was similar for testing memory in the same or different context (p < 0.001). Independent of sleep and wakefulness during the retention interval, animals showed faster relearning when tested in the same context as during learning, compared with testing in a different context (p < 0.001). The benefitting effect of sleep on discrimination learning was primarily due to an enhancing effect on response suppression during the nogo stimulus. We infer from these results that sleep enhances memory for inhibitory behavioral control in a generalized context-independent manner and thereby might eventually also contribute to the abstraction of schema-like representations. Springer Berlin Heidelberg 2013-12-10 2014 /pmc/articles/PMC4010722/ /pubmed/24322821 http://dx.doi.org/10.1007/s00221-013-3797-5 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Research Article
Borquez, Margarita
Born, Jan
Navarro, Victor
Betancourt, Ronald
Inostroza, Marion
Sleep enhances inhibitory behavioral control in discrimination learning in rats
title Sleep enhances inhibitory behavioral control in discrimination learning in rats
title_full Sleep enhances inhibitory behavioral control in discrimination learning in rats
title_fullStr Sleep enhances inhibitory behavioral control in discrimination learning in rats
title_full_unstemmed Sleep enhances inhibitory behavioral control in discrimination learning in rats
title_short Sleep enhances inhibitory behavioral control in discrimination learning in rats
title_sort sleep enhances inhibitory behavioral control in discrimination learning in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010722/
https://www.ncbi.nlm.nih.gov/pubmed/24322821
http://dx.doi.org/10.1007/s00221-013-3797-5
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