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Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells
ROS-GC1 belongs to the Ca(2+)-modulated sub-family of membrane guanylate cyclases. It primarily exists and is linked with signaling of the sensory neurons – sight, smell, taste, and pinealocytes. Exceptionally, it is also present and is Ca(2+)-modulated in t he non-neuronal cells, the sperm cells in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010774/ https://www.ncbi.nlm.nih.gov/pubmed/24808824 http://dx.doi.org/10.3389/fnmol.2014.00034 |
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author | Jankowska, Anna Sharma, Rameshwar K. Duda, Teresa |
author_facet | Jankowska, Anna Sharma, Rameshwar K. Duda, Teresa |
author_sort | Jankowska, Anna |
collection | PubMed |
description | ROS-GC1 belongs to the Ca(2+)-modulated sub-family of membrane guanylate cyclases. It primarily exists and is linked with signaling of the sensory neurons – sight, smell, taste, and pinealocytes. Exceptionally, it is also present and is Ca(2+)-modulated in t he non-neuronal cells, the sperm cells in the testes, where S100B protein serves as its Ca(2+) sensor. The present report demonstrates the identification of an additional Ca(2+) sensor of ROS-GC1 in the testes, neurocalcin δ. Through mouse molecular genetic models, it compares and quantifies the relative input of the S100B and neurocalcin δ in regulating the Ca(2+) signaling of ROS-GC1 transduction machinery, and via immunochemistry it demonstrates the co-presence of neurocalcin δ and ROS-GC1 in the spermatogenic cells of the testes. The suggestion is that in more ways than one the Ca(2+)-modulated ROS-GC1 transduction system is linked with the testicular function. This non-neuronal transduction system may represent an illustration of the ROS-GC1 expanding role in the trans-signaling of the neural and non-neural systems. |
format | Online Article Text |
id | pubmed-4010774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-40107742014-05-07 Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells Jankowska, Anna Sharma, Rameshwar K. Duda, Teresa Front Mol Neurosci Neuroscience ROS-GC1 belongs to the Ca(2+)-modulated sub-family of membrane guanylate cyclases. It primarily exists and is linked with signaling of the sensory neurons – sight, smell, taste, and pinealocytes. Exceptionally, it is also present and is Ca(2+)-modulated in t he non-neuronal cells, the sperm cells in the testes, where S100B protein serves as its Ca(2+) sensor. The present report demonstrates the identification of an additional Ca(2+) sensor of ROS-GC1 in the testes, neurocalcin δ. Through mouse molecular genetic models, it compares and quantifies the relative input of the S100B and neurocalcin δ in regulating the Ca(2+) signaling of ROS-GC1 transduction machinery, and via immunochemistry it demonstrates the co-presence of neurocalcin δ and ROS-GC1 in the spermatogenic cells of the testes. The suggestion is that in more ways than one the Ca(2+)-modulated ROS-GC1 transduction system is linked with the testicular function. This non-neuronal transduction system may represent an illustration of the ROS-GC1 expanding role in the trans-signaling of the neural and non-neural systems. Frontiers Media S.A. 2014-04-29 /pmc/articles/PMC4010774/ /pubmed/24808824 http://dx.doi.org/10.3389/fnmol.2014.00034 Text en Copyright © 2014 Jankowska, Sharma and Duda. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Jankowska, Anna Sharma, Rameshwar K. Duda, Teresa Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells |
title | Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells |
title_full | Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells |
title_fullStr | Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells |
title_full_unstemmed | Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells |
title_short | Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells |
title_sort | ca(2+)-modulated ros-gc1 transduction system in testes and its presence in the spermatogenic cells |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010774/ https://www.ncbi.nlm.nih.gov/pubmed/24808824 http://dx.doi.org/10.3389/fnmol.2014.00034 |
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