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Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells

ROS-GC1 belongs to the Ca(2+)-modulated sub-family of membrane guanylate cyclases. It primarily exists and is linked with signaling of the sensory neurons – sight, smell, taste, and pinealocytes. Exceptionally, it is also present and is Ca(2+)-modulated in t he non-neuronal cells, the sperm cells in...

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Autores principales: Jankowska, Anna, Sharma, Rameshwar K., Duda, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010774/
https://www.ncbi.nlm.nih.gov/pubmed/24808824
http://dx.doi.org/10.3389/fnmol.2014.00034
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author Jankowska, Anna
Sharma, Rameshwar K.
Duda, Teresa
author_facet Jankowska, Anna
Sharma, Rameshwar K.
Duda, Teresa
author_sort Jankowska, Anna
collection PubMed
description ROS-GC1 belongs to the Ca(2+)-modulated sub-family of membrane guanylate cyclases. It primarily exists and is linked with signaling of the sensory neurons – sight, smell, taste, and pinealocytes. Exceptionally, it is also present and is Ca(2+)-modulated in t he non-neuronal cells, the sperm cells in the testes, where S100B protein serves as its Ca(2+) sensor. The present report demonstrates the identification of an additional Ca(2+) sensor of ROS-GC1 in the testes, neurocalcin δ. Through mouse molecular genetic models, it compares and quantifies the relative input of the S100B and neurocalcin δ in regulating the Ca(2+) signaling of ROS-GC1 transduction machinery, and via immunochemistry it demonstrates the co-presence of neurocalcin δ and ROS-GC1 in the spermatogenic cells of the testes. The suggestion is that in more ways than one the Ca(2+)-modulated ROS-GC1 transduction system is linked with the testicular function. This non-neuronal transduction system may represent an illustration of the ROS-GC1 expanding role in the trans-signaling of the neural and non-neural systems.
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spelling pubmed-40107742014-05-07 Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells Jankowska, Anna Sharma, Rameshwar K. Duda, Teresa Front Mol Neurosci Neuroscience ROS-GC1 belongs to the Ca(2+)-modulated sub-family of membrane guanylate cyclases. It primarily exists and is linked with signaling of the sensory neurons – sight, smell, taste, and pinealocytes. Exceptionally, it is also present and is Ca(2+)-modulated in t he non-neuronal cells, the sperm cells in the testes, where S100B protein serves as its Ca(2+) sensor. The present report demonstrates the identification of an additional Ca(2+) sensor of ROS-GC1 in the testes, neurocalcin δ. Through mouse molecular genetic models, it compares and quantifies the relative input of the S100B and neurocalcin δ in regulating the Ca(2+) signaling of ROS-GC1 transduction machinery, and via immunochemistry it demonstrates the co-presence of neurocalcin δ and ROS-GC1 in the spermatogenic cells of the testes. The suggestion is that in more ways than one the Ca(2+)-modulated ROS-GC1 transduction system is linked with the testicular function. This non-neuronal transduction system may represent an illustration of the ROS-GC1 expanding role in the trans-signaling of the neural and non-neural systems. Frontiers Media S.A. 2014-04-29 /pmc/articles/PMC4010774/ /pubmed/24808824 http://dx.doi.org/10.3389/fnmol.2014.00034 Text en Copyright © 2014 Jankowska, Sharma and Duda. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Jankowska, Anna
Sharma, Rameshwar K.
Duda, Teresa
Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells
title Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells
title_full Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells
title_fullStr Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells
title_full_unstemmed Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells
title_short Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells
title_sort ca(2+)-modulated ros-gc1 transduction system in testes and its presence in the spermatogenic cells
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010774/
https://www.ncbi.nlm.nih.gov/pubmed/24808824
http://dx.doi.org/10.3389/fnmol.2014.00034
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