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Enzymatic Synthesis of Bioinformatically Predicted Microcin C-Like Compounds Encoded by Diverse Bacteria

The Trojan horse Escherichia coli antibiotic microcin C (McC) consists of a heptapeptide attached to adenosine through a phosphoramidate linkage. McC is synthesized by the MccB enzyme, which terminally adenylates the ribosomally synthesized heptapeptide precursor MccA. The peptide part is responsibl...

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Detalles Bibliográficos
Autores principales: Bantysh, Olga, Serebryakova, Marina, Makarova, Kira S., Dubiley, Svetlana, Datsenko, Kirill A., Severinov, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010828/
https://www.ncbi.nlm.nih.gov/pubmed/24803518
http://dx.doi.org/10.1128/mBio.01059-14