IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies

The molecular mechanisms that link IFN-λ3 genotypes to differential induction of interferon (IFN)-stimulated genes (ISGs) in the liver of patients with chronic hepatitis C (CHC) are not known. We measured the expression of IFN-λ and of the specific IFN-λ receptor chain (IFN-λR1) in 122 liver biopsie...

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Detalles Bibliográficos
Autores principales: Duong, Francois H.T., Trincucci, Gaia, Boldanova, Tujana, Calabrese, Diego, Campana, Benedetta, Krol, Ilona, Durand, Sarah C., Heydmann, Laura, Zeisel, Mirjam B., Baumert, Thomas F., Heim, Markus H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010915/
https://www.ncbi.nlm.nih.gov/pubmed/24752298
http://dx.doi.org/10.1084/jem.20131557

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