Cargando…

Higher Desolvation Energy Reduces Molecular Recognition in Multi-Drug Resistant HIV-1 Protease

Designing HIV-1 protease inhibitors that overcome drug-resistance is still a challenging task. In this study, four clinical isolates of multi-drug resistant HIV-1 proteases that exhibit resistance to all the US FDA-approved HIV-1 protease inhibitors and also reduce the substrate recognition ability...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yong, Dewdney, Tamaria G., Liu, Zhigang, Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011036/ https://www.ncbi.nlm.nih.gov/pubmed/24832048 http://dx.doi.org/10.3390/biology1010081

Ejemplares similares

The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops
por: Kuiper, Benjamin D., et al.
Publicado: (2015)

The role of mutations at codons 32, 47, 54, and 90 in HIV-1 protease flap dynamics
por: Chordia, Poorvi, et al.
Publicado: (2014)

Topochemical control in desolvation of coordination polymers
por: Lusi, Matteo
Publicado: (2015)

Desolvation Processes in Channel Solvates of Niclosamide
por: Mann, Jen E., et al.
Publicado: (2023)

Unveiling the self-association and desolvation in crystal nucleation
por: Li, Danning, et al.
Publicado: (2021)

GitLab use at CERN: keeping the illusion of a monorepo
por: Kovari, Zsolt
Publicado: (2018)

Role of Desolvation in Thermodynamics and Kinetics of Ligand Binding to a Kinase
por: Mondal, Jagannath, et al.
Publicado: (2014)

The Augmenting Effects of Desolvation and Conformational Energy Terms on the Predictions of Docking Programs against mPGES-1
por: Gupta, Ashish, et al.
Publicado: (2015)

New Timing Sequencer Application in Python with Qt - Development Workflow and Lessons Learnt
por: Kovari, Zsolt, et al.
Publicado: (2022)

Confinement, Desolvation, And Electrosorption Effects on the Diffusion of Ions in Nanoporous Carbon Electrodes
por: Pean, Clarisse, et al.
Publicado: (2015)

Formation and Stability of Pea Proteins Nanoparticles Using Ethanol-Induced Desolvation
por: Doan, Chi Diem, et al.
Publicado: (2019)

Measurement of Solvation Ability of Solvents by Porphyrin-Based Solvation/Desolvation Indicators
por: Sugimoto, Motonobu, et al.
Publicado: (2020)

Upper Gastrointestinal Tract Involvement in Inflammatory Bowel Diseases: Histologic Clues and Pitfalls
por: Kővári, Bence, et al.
Publicado: (2022)

Desolvation and Development of Specific Hydrophobic Core Packing during Im7 Folding
por: Bartlett, Alice I., et al.
Publicado: (2010)

Subclinical Atherosclerosis Imaging in People Living with HIV
por: Schoepf, Isabella C., et al.
Publicado: (2019)

Quantifying the energetic contributions of desolvation and π-electron density during translesion DNA synthesis
por: Motea, Edward A., et al.
Publicado: (2011)

Transpedicular direct osteosynthesis of hangman's fracture from a mini-open exposure as a less invasive procedure: A technical note
por: Kovari, Viktor Zsolt, et al.
Publicado: (2017)

Pulmonary Toxoplasmosis, a Rare but Severe Manifestation of a Common Opportunistic Infection in Late HIV Presenters: Report of Two Cases
por: Kovari, H., et al.
Publicado: (2010)

Interdependence of Inhibitor Recognition in HIV-1 Protease
por: Paulsen, Janet L., et al.
Publicado: (2017)

A theoretical investigation of DNA dynamics and desolvation kinetics for zinc finger proteinZif268
por: Dutta, Shayoni, et al.
Publicado: (2015)

The role of surface charge in the desolvation process of gelatin: implications in nanoparticle synthesis and modulation of drug release
por: Ahsan, Saad M, et al.
Publicado: (2017)

3D-Printed Paper Spray Ionization Cartridge with Integrated Desolvation Feature and Ion Optics
por: Salentijn, G. IJ., et al.
Publicado: (2017)

Acute Mechanical Performance of Magmaris vs. DESolve Bioresorbable Scaffolds in a Real-World Scenario
por: Boeder, Niklas F., et al.
Publicado: (2021)

Suppressing electrolyte-lithium metal reactivity via Li(+)-desolvation in uniform nano-porous separator
por: Sheng, Li, et al.
Publicado: (2022)

Proteins with Highly Similar Native Folds Can Show Vastly Dissimilar Folding Behavior When Desolvated**
por: Schennach, Moritz, et al.
Publicado: (2014)

Insight into the role of pre-assembly and desolvation in crystal nucleation: a case of p-nitrobenzoic acid
por: Zong, Shuyi, et al.
Publicado: (2019)

Step-by-step desolvation enables high-rate and ultra-stable sodium storage in hard carbon anodes
por: Lu, Ziyang, et al.
Publicado: (2022)

Regulating Zn Ion Desolvation and Deposition Chemistry Toward Durable and Fast Rechargeable Zn Metal Batteries
por: Zhou, Yuhang, et al.
Publicado: (2022)

High precision measurements of lithium isotopic composition at sub-nanogram by MC-ICP-MS with membrane desolvation
por: He, Mao-Yong, et al.
Publicado: (2023)

Incidental Findings on Coronary Computed Tomography Angiography in Human Immunodeficiency Virus (HIV)-Positive and HIV-Negative Persons
por: Reinschmidt, Sara, et al.
Publicado: (2018)

CBNG - The new build tool used to build millions of lines of Java code at CERN
por: Cseppento, Lajos, et al.
Publicado: (2018)

Initial experience with the treatment of concomitant aortic pseudoaneurysm and thoracolumbar spinal fracture: Case report
por: Kovari, Viktor Zsolt, et al.
Publicado: (2017)

Apocrine Encapsulated Papillary Carcinoma of the Breast: The First Reported Case with an Infiltrative Component
por: Kővári, Bence, et al.
Publicado: (2018)

Proteins mediating DNA loops effectively block transcription
por: Vörös, Zsuzsanna, et al.
Publicado: (2017)

The mechanism of solvent-mediated desolvation transformation of lenvatinib mesylate from dimethyl sulfoxide solvate to form D
por: Zheng, Zhixin, et al.
Publicado: (2020)

Desolvation of the substrate-binding protein TauA dictates ligand specificity for the alkanesulfonate ABC importer TauABC
por: Qu, Feng, et al.
Publicado: (2019)

Cryo-EM reveals a novel octameric integrase structure for β-retroviral intasome function
por: Ballandras-Colas, Allison, et al.
Publicado: (2016)

Brain Aging in the Oldest-Old
por: von Gunten, A., et al.
Publicado: (2010)

The effects of Tiszasüly and Kolop mud pack therapy on knee osteoarthritis: a double-blind, randomised, non-inferiority controlled study
por: Király, Márta, et al.
Publicado: (2019)

Syntaxin 1: A Novel Robust Immunophenotypic Marker of Neuroendocrine Tumors
por: Kővári, Bence, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7pvglsrtoeqan3j1ugl99e9ee5