l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation

Several studies showed that l-leucine supplementation reduces adiposity when provided before the onset of obesity. We studied rats that were exposed to a high-fat diet (HFD) for 10 weeks before they started to receive l-leucine supplementation. Fat mass was increased in l-leucine-supplemented rats c...

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Detalles Bibliográficos
Autores principales: Zampieri, Thais T., Torres-Leal, Francisco L., Campaña, Amanda B., Lima, Fabio B., Donato, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011039/
https://www.ncbi.nlm.nih.gov/pubmed/24699194
http://dx.doi.org/10.3390/nu6041364
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author Zampieri, Thais T.
Torres-Leal, Francisco L.
Campaña, Amanda B.
Lima, Fabio B.
Donato, Jose
author_facet Zampieri, Thais T.
Torres-Leal, Francisco L.
Campaña, Amanda B.
Lima, Fabio B.
Donato, Jose
author_sort Zampieri, Thais T.
collection PubMed
description Several studies showed that l-leucine supplementation reduces adiposity when provided before the onset of obesity. We studied rats that were exposed to a high-fat diet (HFD) for 10 weeks before they started to receive l-leucine supplementation. Fat mass was increased in l-leucine-supplemented rats consuming the HFD. Accordingly, l-leucine produced a hypothalamic pattern of gene expression that favors fat accumulation. In conclusion, l-leucine supplementation worsened the adiposity of rats previously exposed to HFD possibly by central mechanisms.
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spelling pubmed-40110392014-05-06 l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation Zampieri, Thais T. Torres-Leal, Francisco L. Campaña, Amanda B. Lima, Fabio B. Donato, Jose Nutrients Short Communication Several studies showed that l-leucine supplementation reduces adiposity when provided before the onset of obesity. We studied rats that were exposed to a high-fat diet (HFD) for 10 weeks before they started to receive l-leucine supplementation. Fat mass was increased in l-leucine-supplemented rats consuming the HFD. Accordingly, l-leucine produced a hypothalamic pattern of gene expression that favors fat accumulation. In conclusion, l-leucine supplementation worsened the adiposity of rats previously exposed to HFD possibly by central mechanisms. MDPI 2014-04-02 /pmc/articles/PMC4011039/ /pubmed/24699194 http://dx.doi.org/10.3390/nu6041364 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Short Communication
Zampieri, Thais T.
Torres-Leal, Francisco L.
Campaña, Amanda B.
Lima, Fabio B.
Donato, Jose
l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation
title l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation
title_full l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation
title_fullStr l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation
title_full_unstemmed l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation
title_short l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation
title_sort l-leucine supplementation worsens the adiposity of already obese rats by promoting a hypothalamic pattern of gene expression that favors fat accumulation
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011039/
https://www.ncbi.nlm.nih.gov/pubmed/24699194
http://dx.doi.org/10.3390/nu6041364
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