Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline

This review is focused upon the role of ascorbic acid (AA, vitamin C) in the promotion of healthy brain aging. Particular attention is attributed to the biochemistry and neuronal metabolism interface, transport across tissues, animal models that are useful for this area of research, and the human st...

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Detalles Bibliográficos
Autores principales: Harrison, Fiona E., Bowman, Gene L., Polidori, Maria Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011065/
https://www.ncbi.nlm.nih.gov/pubmed/24763117
http://dx.doi.org/10.3390/nu6041752
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author Harrison, Fiona E.
Bowman, Gene L.
Polidori, Maria Cristina
author_facet Harrison, Fiona E.
Bowman, Gene L.
Polidori, Maria Cristina
author_sort Harrison, Fiona E.
collection PubMed
description This review is focused upon the role of ascorbic acid (AA, vitamin C) in the promotion of healthy brain aging. Particular attention is attributed to the biochemistry and neuronal metabolism interface, transport across tissues, animal models that are useful for this area of research, and the human studies that implicate AA in the continuum between normal cognitive aging and age-related cognitive decline up to Alzheimer’s disease. Vascular risk factors and comorbidity relationships with cognitive decline and AA are discussed to facilitate strategies for advancing AA research in the area of brain health and neurodegeneration.
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spelling pubmed-40110652014-05-06 Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline Harrison, Fiona E. Bowman, Gene L. Polidori, Maria Cristina Nutrients Review This review is focused upon the role of ascorbic acid (AA, vitamin C) in the promotion of healthy brain aging. Particular attention is attributed to the biochemistry and neuronal metabolism interface, transport across tissues, animal models that are useful for this area of research, and the human studies that implicate AA in the continuum between normal cognitive aging and age-related cognitive decline up to Alzheimer’s disease. Vascular risk factors and comorbidity relationships with cognitive decline and AA are discussed to facilitate strategies for advancing AA research in the area of brain health and neurodegeneration. MDPI 2014-04-24 /pmc/articles/PMC4011065/ /pubmed/24763117 http://dx.doi.org/10.3390/nu6041752 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Harrison, Fiona E.
Bowman, Gene L.
Polidori, Maria Cristina
Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline
title Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline
title_full Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline
title_fullStr Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline
title_full_unstemmed Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline
title_short Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline
title_sort ascorbic acid and the brain: rationale for the use against cognitive decline
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011065/
https://www.ncbi.nlm.nih.gov/pubmed/24763117
http://dx.doi.org/10.3390/nu6041752
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