Prospective study of Hepatitis E Virus infection among pregnant women in France

BACKGROUND: Hepatitis E Virus (HEV) infection has a poor prognosis among pregnant women from high endemic countries. HEV-prevalence and incidence among pregnant women is unknown in high-income countries such as France. This prospective study was conducted to assess HEV infection in this setting. FIN...

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Autores principales: Renou, Christophe, Gobert, Vincent, Locher, Christophe, Moumen, Abdelouahab, Timbely, Oumar, Savary, Janine, Roque-Afonso, Anne-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011159/
https://www.ncbi.nlm.nih.gov/pubmed/24716485
http://dx.doi.org/10.1186/1743-422X-11-68
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author Renou, Christophe
Gobert, Vincent
Locher, Christophe
Moumen, Abdelouahab
Timbely, Oumar
Savary, Janine
Roque-Afonso, Anne-Marie
author_facet Renou, Christophe
Gobert, Vincent
Locher, Christophe
Moumen, Abdelouahab
Timbely, Oumar
Savary, Janine
Roque-Afonso, Anne-Marie
author_sort Renou, Christophe
collection PubMed
description BACKGROUND: Hepatitis E Virus (HEV) infection has a poor prognosis among pregnant women from high endemic countries. HEV-prevalence and incidence among pregnant women is unknown in high-income countries such as France. This prospective study was conducted to assess HEV infection in this setting. FINDINGS: An overall HEV prevalence of 7.74% was observed among 315 pregnant women. Seroprevalence was higher in south than in north of France (29.3% vs. 3.6%, p < 0.0001), and women with detectable IgG were older. No IgG seroconversion or IgM detection were observed during pregnancy. CONCLUSIONS: Data suggest that HEV infection is a rare occurrence during pregnancy even in regions of western countries with high seroprevalence rates.
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spelling pubmed-40111592014-05-07 Prospective study of Hepatitis E Virus infection among pregnant women in France Renou, Christophe Gobert, Vincent Locher, Christophe Moumen, Abdelouahab Timbely, Oumar Savary, Janine Roque-Afonso, Anne-Marie Virol J Short Report BACKGROUND: Hepatitis E Virus (HEV) infection has a poor prognosis among pregnant women from high endemic countries. HEV-prevalence and incidence among pregnant women is unknown in high-income countries such as France. This prospective study was conducted to assess HEV infection in this setting. FINDINGS: An overall HEV prevalence of 7.74% was observed among 315 pregnant women. Seroprevalence was higher in south than in north of France (29.3% vs. 3.6%, p < 0.0001), and women with detectable IgG were older. No IgG seroconversion or IgM detection were observed during pregnancy. CONCLUSIONS: Data suggest that HEV infection is a rare occurrence during pregnancy even in regions of western countries with high seroprevalence rates. BioMed Central 2014-04-09 /pmc/articles/PMC4011159/ /pubmed/24716485 http://dx.doi.org/10.1186/1743-422X-11-68 Text en Copyright © 2014 Renou et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Renou, Christophe
Gobert, Vincent
Locher, Christophe
Moumen, Abdelouahab
Timbely, Oumar
Savary, Janine
Roque-Afonso, Anne-Marie
Prospective study of Hepatitis E Virus infection among pregnant women in France
title Prospective study of Hepatitis E Virus infection among pregnant women in France
title_full Prospective study of Hepatitis E Virus infection among pregnant women in France
title_fullStr Prospective study of Hepatitis E Virus infection among pregnant women in France
title_full_unstemmed Prospective study of Hepatitis E Virus infection among pregnant women in France
title_short Prospective study of Hepatitis E Virus infection among pregnant women in France
title_sort prospective study of hepatitis e virus infection among pregnant women in france
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011159/
https://www.ncbi.nlm.nih.gov/pubmed/24716485
http://dx.doi.org/10.1186/1743-422X-11-68
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