Revitalizing Personalized Medicine: Respecting Biomolecular Complexities Beyond Gene Expression

Despite recent advancements in “omic” technologies, personalized medicine has not realized its fullest potential due to isolated and incomplete application of gene expression tools. In many instances, pharmacogenomics is being interchangeably used for personalized medicine, when actually it is one o...

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Detalles Bibliográficos
Autores principales: Jayachandran, D, Ramkrishna, U, Skiles, J, Renbarger, J, Ramkrishna, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011166/
https://www.ncbi.nlm.nih.gov/pubmed/24739991
http://dx.doi.org/10.1038/psp.2014.6
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author Jayachandran, D
Ramkrishna, U
Skiles, J
Renbarger, J
Ramkrishna, D
author_facet Jayachandran, D
Ramkrishna, U
Skiles, J
Renbarger, J
Ramkrishna, D
author_sort Jayachandran, D
collection PubMed
description Despite recent advancements in “omic” technologies, personalized medicine has not realized its fullest potential due to isolated and incomplete application of gene expression tools. In many instances, pharmacogenomics is being interchangeably used for personalized medicine, when actually it is one of the many facets of personalized medicine. Herein, we highlight key issues that are hampering the advancement of personalized medicine and highlight emerging predictive tools that can serve as a decision support mechanism for physicians to personalize treatments.
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spelling pubmed-40111662014-05-13 Revitalizing Personalized Medicine: Respecting Biomolecular Complexities Beyond Gene Expression Jayachandran, D Ramkrishna, U Skiles, J Renbarger, J Ramkrishna, D CPT Pharmacometrics Syst Pharmacol Review Despite recent advancements in “omic” technologies, personalized medicine has not realized its fullest potential due to isolated and incomplete application of gene expression tools. In many instances, pharmacogenomics is being interchangeably used for personalized medicine, when actually it is one of the many facets of personalized medicine. Herein, we highlight key issues that are hampering the advancement of personalized medicine and highlight emerging predictive tools that can serve as a decision support mechanism for physicians to personalize treatments. Nature Publishing Group 2014-04 2014-04-16 /pmc/articles/PMC4011166/ /pubmed/24739991 http://dx.doi.org/10.1038/psp.2014.6 Text en Copyright © 2014 American Society for Clinical Pharmacology and Therapeutics http://creativecommons.org/licenses/by-nc-nd/3.0/ CPT: Pharmacometrics and Systems Pharmacology is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Review
Jayachandran, D
Ramkrishna, U
Skiles, J
Renbarger, J
Ramkrishna, D
Revitalizing Personalized Medicine: Respecting Biomolecular Complexities Beyond Gene Expression
title Revitalizing Personalized Medicine: Respecting Biomolecular Complexities Beyond Gene Expression
title_full Revitalizing Personalized Medicine: Respecting Biomolecular Complexities Beyond Gene Expression
title_fullStr Revitalizing Personalized Medicine: Respecting Biomolecular Complexities Beyond Gene Expression
title_full_unstemmed Revitalizing Personalized Medicine: Respecting Biomolecular Complexities Beyond Gene Expression
title_short Revitalizing Personalized Medicine: Respecting Biomolecular Complexities Beyond Gene Expression
title_sort revitalizing personalized medicine: respecting biomolecular complexities beyond gene expression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011166/
https://www.ncbi.nlm.nih.gov/pubmed/24739991
http://dx.doi.org/10.1038/psp.2014.6
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