SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway

The HECT domain-containing ubiquitin E3 ligase NEDD4 is widely expressed in mammalian tissues and plays a crucial role in governing a wide spectrum of cellular processes including cell growth, tissue development and homeostasis. Recent reports have indicated that NEDD4 might facilitate tumorigenesis...

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Detalles Bibliográficos
Autores principales: Liu, Jia, Wan, Lixin, Liu, Pengda, Inuzuka, Hiroyuki, Liu, Jiankang, Wang, Zhiwei, Wei, Wenyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011580/
https://www.ncbi.nlm.nih.gov/pubmed/24657926

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