Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR

Indoleamine-2,3-dioxygenase (IDO) inhibitors have entered clinical trials based on their ability to restore anti-tumor immunity in preclinical studies. However, the mechanisms leading to constitutive expression of IDO in human tumors are largely unknown. Here we analyzed the pathways mediating const...

Descripción completa

Detalles Bibliográficos
Autores principales: Litzenburger, Ulrike M., Opitz, Christiane A., Sahm, Felix, Rauschenbach, Katharina J., Trump, Saskia, Winter, Marcus, Ott, Martina, Ochs, Katharina, Lutz, Christian, Liu, Xiangdong, Anastasov, Natasa, Lehmann, Irina, Höfer, Thomas, von Deimling, Andreas, Wick, Wolfgang, Platten, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011581/
https://www.ncbi.nlm.nih.gov/pubmed/24657910

Ejemplares similares

Ejemplares similares