miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1

The serine threonine kinase Akt1 has been implicated in the control of cellular metabolism, survival and growth. Herein, disruption of the ubiquitously expressed member of the Akt family of genes, Akt1, in the mouse, demonstrates a requirement for Akt1 in miRNA-mediated cellular apoptosis. The miR-1...

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Detalles Bibliográficos
Autores principales: Yu, Zuoren, Xu, Zengguang, DiSante, Gabriele, Wright, Jennifer, Wang, Min, Li, Yuan, Zhao, Qian, Ren, Tao, Ju, Xiaoming, Gutman, Ellen, Wang, Guangxue, Addya, Sankar, Li, Tieyan, Xiang, Zhendong, Wang, Chenguang, yang, Xiongfei, Yang, Xiaolai, Pestell, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011585/
https://www.ncbi.nlm.nih.gov/pubmed/24658544

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