High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia

Although p53 is found mutated in almost 50% of all cancers, p53 mutations in leukaemia are relatively rare. Acute myeloid leukaemia (AML) cells employ other strategies to inactivate their wild type p53 (WTp53), like the overexpression of the p53 negative regulators Mdm2 and Mdm4. As such, AMLs are e...

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Detalles Bibliográficos
Autores principales: Tan, Ban Xiong, Khoo, Kian Hoe, Lim, Tit Meng, Lane, David Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011595/
https://www.ncbi.nlm.nih.gov/pubmed/24659749

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