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Effects of Zaprinast and Rolipram on Olfactory and Visual Memory in the Social Transmission of Food Preference and Novel Object Recognition Tests in Mice

The role of phosphodiesterase (PDE) inhibitors in central nervous system has been investigated and shown to stimulate neuronal functions and increase neurogenesis in Alzheimer patients. The aim of this study is to investigate effect of PDE5 inhibitor zaprinast and PDE4 inhibitor rolipram on visual m...

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Autores principales: Akar, Furuzan, Mutlu, Oguz, Celikyurt, Ipek K, Bektas, Emine, Tanyeri, Mehmet H, Ulak, Guner, Tanyeri, Pelin, Erden, Faruk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011720/
https://www.ncbi.nlm.nih.gov/pubmed/24855335
http://dx.doi.org/10.4137/DTI.S14813
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author Akar, Furuzan
Mutlu, Oguz
Celikyurt, Ipek K
Bektas, Emine
Tanyeri, Mehmet H
Ulak, Guner
Tanyeri, Pelin
Erden, Faruk
author_facet Akar, Furuzan
Mutlu, Oguz
Celikyurt, Ipek K
Bektas, Emine
Tanyeri, Mehmet H
Ulak, Guner
Tanyeri, Pelin
Erden, Faruk
author_sort Akar, Furuzan
collection PubMed
description The role of phosphodiesterase (PDE) inhibitors in central nervous system has been investigated and shown to stimulate neuronal functions and increase neurogenesis in Alzheimer patients. The aim of this study is to investigate effect of PDE5 inhibitor zaprinast and PDE4 inhibitor rolipram on visual memory in novel object recognition (NOR) test, on olfactory memory in social transmission of food preference (STFP) test, and also on locomotion and anxiety in open field test in naive mice. Male Balb-c mice were treated intraperitoneally (i.p.) with zaprinast (3 and 10 mg/kg), rolipram (0.05 and 0.1 mg/kg), or physiological saline. Zaprinast (10 mg/kg) significantly increased cued/non-cued food eaten compared to control group, while rolipram had a partial effect on retention trial of STFP test. Zaprinast (10 mg/kg) and rolipram (0.05 and 0.1 mg/kg) significantly increased ratio index (RI) compared to control group in retention trial of NOR test. There was no significant effect of zaprinast and rolipram on total distance moved, speed, and center zone duration in open field test. Results of this study revealed that both zaprinast and rolipram enhanced visual memory in NOR test, however zaprinast exerted a significant memory-enhancing effect compared to rolipram in STFP test in mice.
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spelling pubmed-40117202014-05-22 Effects of Zaprinast and Rolipram on Olfactory and Visual Memory in the Social Transmission of Food Preference and Novel Object Recognition Tests in Mice Akar, Furuzan Mutlu, Oguz Celikyurt, Ipek K Bektas, Emine Tanyeri, Mehmet H Ulak, Guner Tanyeri, Pelin Erden, Faruk Drug Target Insights Original Research The role of phosphodiesterase (PDE) inhibitors in central nervous system has been investigated and shown to stimulate neuronal functions and increase neurogenesis in Alzheimer patients. The aim of this study is to investigate effect of PDE5 inhibitor zaprinast and PDE4 inhibitor rolipram on visual memory in novel object recognition (NOR) test, on olfactory memory in social transmission of food preference (STFP) test, and also on locomotion and anxiety in open field test in naive mice. Male Balb-c mice were treated intraperitoneally (i.p.) with zaprinast (3 and 10 mg/kg), rolipram (0.05 and 0.1 mg/kg), or physiological saline. Zaprinast (10 mg/kg) significantly increased cued/non-cued food eaten compared to control group, while rolipram had a partial effect on retention trial of STFP test. Zaprinast (10 mg/kg) and rolipram (0.05 and 0.1 mg/kg) significantly increased ratio index (RI) compared to control group in retention trial of NOR test. There was no significant effect of zaprinast and rolipram on total distance moved, speed, and center zone duration in open field test. Results of this study revealed that both zaprinast and rolipram enhanced visual memory in NOR test, however zaprinast exerted a significant memory-enhancing effect compared to rolipram in STFP test in mice. Libertas Academica 2014-04-29 /pmc/articles/PMC4011720/ /pubmed/24855335 http://dx.doi.org/10.4137/DTI.S14813 Text en © 2014 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article published under the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Original Research
Akar, Furuzan
Mutlu, Oguz
Celikyurt, Ipek K
Bektas, Emine
Tanyeri, Mehmet H
Ulak, Guner
Tanyeri, Pelin
Erden, Faruk
Effects of Zaprinast and Rolipram on Olfactory and Visual Memory in the Social Transmission of Food Preference and Novel Object Recognition Tests in Mice
title Effects of Zaprinast and Rolipram on Olfactory and Visual Memory in the Social Transmission of Food Preference and Novel Object Recognition Tests in Mice
title_full Effects of Zaprinast and Rolipram on Olfactory and Visual Memory in the Social Transmission of Food Preference and Novel Object Recognition Tests in Mice
title_fullStr Effects of Zaprinast and Rolipram on Olfactory and Visual Memory in the Social Transmission of Food Preference and Novel Object Recognition Tests in Mice
title_full_unstemmed Effects of Zaprinast and Rolipram on Olfactory and Visual Memory in the Social Transmission of Food Preference and Novel Object Recognition Tests in Mice
title_short Effects of Zaprinast and Rolipram on Olfactory and Visual Memory in the Social Transmission of Food Preference and Novel Object Recognition Tests in Mice
title_sort effects of zaprinast and rolipram on olfactory and visual memory in the social transmission of food preference and novel object recognition tests in mice
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011720/
https://www.ncbi.nlm.nih.gov/pubmed/24855335
http://dx.doi.org/10.4137/DTI.S14813
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