Matrix Conditions and KLF2-Dependent Induction of Heme Oxygenase-1 Modulate Inhibition of HCV Replication by Fluvastatin

BACKGROUND & AIMS: HMG-CoA-reductase-inhibitors (statins) have been shown to interfere with HCV replication in vitro. We investigated the mechanism, requirements and contribution of heme oxygenase-1(HO-1)-induction by statins to interference with HCV replication. METHODS: HO-1-induction by fluva...

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Detalles Bibliográficos
Autores principales: Wuestenberg, Andrea, Kah, Janine, Singethan, Katrin, Sirma, Hüseyin, Keller, Amelie Dorothea, Rosal, Sergio René Perez, Schrader, Jörg, Loscher, Christine, Volz, Tassilo, Bartenschlager, Ralf, Lohmann, Volker, Protzer, Ulrike, Dandri, Maura, Lohse, Ansgar W., Tiegs, Gisa, Sass, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011762/
https://www.ncbi.nlm.nih.gov/pubmed/24801208
http://dx.doi.org/10.1371/journal.pone.0096533

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