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Protracted Effects of Juvenile Stressor Exposure Are Mitigated by Access to Palatable Food
Stressor experiences during the juvenile period may increase vulnerability to anxiety and depressive-like symptoms in adulthood. Stressors may also promote palatable feeding, possibly reflecting a form of self-medication. The current study investigated the short- and long-term consequences of a stre...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011852/ https://www.ncbi.nlm.nih.gov/pubmed/24801635 http://dx.doi.org/10.1371/journal.pone.0096573 |
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author | MacKay, Jennifer Christine James, Jonathan Stewart Cayer, Christian Kent, Pamela Anisman, Hymie Merali, Zul |
author_facet | MacKay, Jennifer Christine James, Jonathan Stewart Cayer, Christian Kent, Pamela Anisman, Hymie Merali, Zul |
author_sort | MacKay, Jennifer Christine |
collection | PubMed |
description | Stressor experiences during the juvenile period may increase vulnerability to anxiety and depressive-like symptoms in adulthood. Stressors may also promote palatable feeding, possibly reflecting a form of self-medication. The current study investigated the short- and long-term consequences of a stressor applied during the juvenile period on anxiety- and depressive-like behavior measured by the elevated plus maze (EPM), social interaction and forced swim test (FST). Furthermore, the effects of stress on caloric intake, preference for a palatable food and indices of metabolic syndrome and obesity were assessed. Male Wistar rats exposed to 3 consecutive days of variable stressors on postnatal days (PD) 27–29, displayed elevated anxiety-like behaviors as adults, which could be attenuated by consumption of a palatable high-fat diet. However, consumption of a palatable food in response to a stressor appeared to contribute to increased adiposity. |
format | Online Article Text |
id | pubmed-4011852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40118522014-05-09 Protracted Effects of Juvenile Stressor Exposure Are Mitigated by Access to Palatable Food MacKay, Jennifer Christine James, Jonathan Stewart Cayer, Christian Kent, Pamela Anisman, Hymie Merali, Zul PLoS One Research Article Stressor experiences during the juvenile period may increase vulnerability to anxiety and depressive-like symptoms in adulthood. Stressors may also promote palatable feeding, possibly reflecting a form of self-medication. The current study investigated the short- and long-term consequences of a stressor applied during the juvenile period on anxiety- and depressive-like behavior measured by the elevated plus maze (EPM), social interaction and forced swim test (FST). Furthermore, the effects of stress on caloric intake, preference for a palatable food and indices of metabolic syndrome and obesity were assessed. Male Wistar rats exposed to 3 consecutive days of variable stressors on postnatal days (PD) 27–29, displayed elevated anxiety-like behaviors as adults, which could be attenuated by consumption of a palatable high-fat diet. However, consumption of a palatable food in response to a stressor appeared to contribute to increased adiposity. Public Library of Science 2014-05-06 /pmc/articles/PMC4011852/ /pubmed/24801635 http://dx.doi.org/10.1371/journal.pone.0096573 Text en © 2014 MacKay et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article MacKay, Jennifer Christine James, Jonathan Stewart Cayer, Christian Kent, Pamela Anisman, Hymie Merali, Zul Protracted Effects of Juvenile Stressor Exposure Are Mitigated by Access to Palatable Food |
title | Protracted Effects of Juvenile Stressor Exposure Are Mitigated by Access to Palatable Food |
title_full | Protracted Effects of Juvenile Stressor Exposure Are Mitigated by Access to Palatable Food |
title_fullStr | Protracted Effects of Juvenile Stressor Exposure Are Mitigated by Access to Palatable Food |
title_full_unstemmed | Protracted Effects of Juvenile Stressor Exposure Are Mitigated by Access to Palatable Food |
title_short | Protracted Effects of Juvenile Stressor Exposure Are Mitigated by Access to Palatable Food |
title_sort | protracted effects of juvenile stressor exposure are mitigated by access to palatable food |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011852/ https://www.ncbi.nlm.nih.gov/pubmed/24801635 http://dx.doi.org/10.1371/journal.pone.0096573 |
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