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Pulmonary Fissure Integrity and Collateral Ventilation in COPD Patients

PURPOSE: To investigate whether the integrity (completeness) of pulmonary fissures affects pulmonary function in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: A dataset consisting of 573 CT exams acquired on different subjects was collected from a COPD study. Acc...

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Autores principales: Pu, Jiantao, Wang, Zhimin, Gu, Suicheng, Fuhrman, Carl, Leader, Joseph K., Meng, Xin, Tedrow, John, Sciurba, Frank C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011857/
https://www.ncbi.nlm.nih.gov/pubmed/24800803
http://dx.doi.org/10.1371/journal.pone.0096631
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author Pu, Jiantao
Wang, Zhimin
Gu, Suicheng
Fuhrman, Carl
Leader, Joseph K.
Meng, Xin
Tedrow, John
Sciurba, Frank C.
author_facet Pu, Jiantao
Wang, Zhimin
Gu, Suicheng
Fuhrman, Carl
Leader, Joseph K.
Meng, Xin
Tedrow, John
Sciurba, Frank C.
author_sort Pu, Jiantao
collection PubMed
description PURPOSE: To investigate whether the integrity (completeness) of pulmonary fissures affects pulmonary function in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: A dataset consisting of 573 CT exams acquired on different subjects was collected from a COPD study. According to the global initiative for chronic obstructive lung disease (GOLD) criteria, these subjects (examinations) were classified into five different subgroups, namely non-COPD (222 subjects), GOLD-I (83 subjects), GOLD-II (141 subjects), GOLD-III (63 subjects), and GOLD-IV (64 subjects), in terms of disease severity. An available computer tool was used to aid in an objective and efficient quantification of fissure integrity. The correlations between fissure integrity, and pulmonary functions (e.g., FEV1, and FEV1/FVC) and COPD severity were assessed using Pearson and Spearman's correlation coefficients, respectively. RESULTS: For the five sub-groups ranging from non-COPD to GOLD-IV, the average integrities of the right oblique fissure (ROF) were 81.8%, 82.4%, 81.8%, 82.8%, and 80.2%, respectively; the average integrities of the right horizontal fissure (RHF) were 62.6%, 61.8%, 62.1%, 62.2%, and 62.3%, respectively; the average integrities of the left oblique fissure (LOF) were 82.0%, 83.2%, 81.7%, 82.0%, and 78.4%, respectively; and the average integrities of all fissures in the entire lung were 78.0%, 78.6%, 78.1%, 78.5%, and 76.4%, respectively. Their Pearson correlation coefficients with FEV1 and FE1/FVC range from 0.027 to 0.248 with p values larger than 0.05. Their Spearman correlation coefficients with COPD severity except GOLD-IV range from −0.013 to −0.073 with p values larger than 0.08. CONCLUSION: There is no significant difference in fissure integrity for patients with different levels of disease severity, suggesting that the development of COPD does not change the completeness of pulmonary fissures and incomplete fissures alone may not contribute to the collateral ventilation.
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spelling pubmed-40118572014-05-09 Pulmonary Fissure Integrity and Collateral Ventilation in COPD Patients Pu, Jiantao Wang, Zhimin Gu, Suicheng Fuhrman, Carl Leader, Joseph K. Meng, Xin Tedrow, John Sciurba, Frank C. PLoS One Research Article PURPOSE: To investigate whether the integrity (completeness) of pulmonary fissures affects pulmonary function in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: A dataset consisting of 573 CT exams acquired on different subjects was collected from a COPD study. According to the global initiative for chronic obstructive lung disease (GOLD) criteria, these subjects (examinations) were classified into five different subgroups, namely non-COPD (222 subjects), GOLD-I (83 subjects), GOLD-II (141 subjects), GOLD-III (63 subjects), and GOLD-IV (64 subjects), in terms of disease severity. An available computer tool was used to aid in an objective and efficient quantification of fissure integrity. The correlations between fissure integrity, and pulmonary functions (e.g., FEV1, and FEV1/FVC) and COPD severity were assessed using Pearson and Spearman's correlation coefficients, respectively. RESULTS: For the five sub-groups ranging from non-COPD to GOLD-IV, the average integrities of the right oblique fissure (ROF) were 81.8%, 82.4%, 81.8%, 82.8%, and 80.2%, respectively; the average integrities of the right horizontal fissure (RHF) were 62.6%, 61.8%, 62.1%, 62.2%, and 62.3%, respectively; the average integrities of the left oblique fissure (LOF) were 82.0%, 83.2%, 81.7%, 82.0%, and 78.4%, respectively; and the average integrities of all fissures in the entire lung were 78.0%, 78.6%, 78.1%, 78.5%, and 76.4%, respectively. Their Pearson correlation coefficients with FEV1 and FE1/FVC range from 0.027 to 0.248 with p values larger than 0.05. Their Spearman correlation coefficients with COPD severity except GOLD-IV range from −0.013 to −0.073 with p values larger than 0.08. CONCLUSION: There is no significant difference in fissure integrity for patients with different levels of disease severity, suggesting that the development of COPD does not change the completeness of pulmonary fissures and incomplete fissures alone may not contribute to the collateral ventilation. Public Library of Science 2014-05-06 /pmc/articles/PMC4011857/ /pubmed/24800803 http://dx.doi.org/10.1371/journal.pone.0096631 Text en © 2014 Pu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Pu, Jiantao
Wang, Zhimin
Gu, Suicheng
Fuhrman, Carl
Leader, Joseph K.
Meng, Xin
Tedrow, John
Sciurba, Frank C.
Pulmonary Fissure Integrity and Collateral Ventilation in COPD Patients
title Pulmonary Fissure Integrity and Collateral Ventilation in COPD Patients
title_full Pulmonary Fissure Integrity and Collateral Ventilation in COPD Patients
title_fullStr Pulmonary Fissure Integrity and Collateral Ventilation in COPD Patients
title_full_unstemmed Pulmonary Fissure Integrity and Collateral Ventilation in COPD Patients
title_short Pulmonary Fissure Integrity and Collateral Ventilation in COPD Patients
title_sort pulmonary fissure integrity and collateral ventilation in copd patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011857/
https://www.ncbi.nlm.nih.gov/pubmed/24800803
http://dx.doi.org/10.1371/journal.pone.0096631
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