Cargando…

Quantitative cumulative biodistribution of antibodies in mice: Effect of modulating binding affinity to the neonatal Fc receptor

The neonatal Fc receptor (FcRn) plays an important and well-known role in antibody recycling in endothelial and hematopoietic cells and thus it influences the systemic pharmacokinetics (PK) of immunoglobulin G (IgG). However, considerably less is known about FcRn’s role in the metabolism of IgG with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yip, Victor, Palma, Enzo, Tesar, Devin B, Mundo, Eduardo E, Bumbaca, Daniela, Torres, Elizabeth K, Reyes, Noe A, Shen, Ben Q, Fielder, Paul J, Prabhu, Saileta, Khawli, Leslie A, Boswell, C Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2014
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011913/ https://www.ncbi.nlm.nih.gov/pubmed/24572100 http://dx.doi.org/10.4161/mabs.28254

Ejemplares similares

Effects of Anti-VEGF on Predicted Antibody Biodistribution: Roles of Vascular Volume, Interstitial Volume, and Blood Flow
por: Boswell, C. Andrew, et al.
Publicado: (2011)

Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer
por: Boswell, C. Andrew, et al.
Publicado: (2019)

Selection of bispecific antibodies with optimal developability using FcRn‑Ph‑HPLC as an optimized FcRn affinity chromatography method
por: Müller, Thomas, et al.
Publicado: (2023)

Ligand Valency Affects Transcytosis, Recycling and Intracellular Trafficking Mediated by the Neonatal Fc Receptor
por: Tesar, Devin B, et al.
Publicado: (2006)

An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans
por: Chung, Shan, et al.
Publicado: (2019)

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice
por: Kamath, Amrita V, et al.
Publicado: (2014)

Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity
por: Sun, Yue, et al.
Publicado: (2020)

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity
por: Abdiche, Yasmina Noubia, et al.
Publicado: (2015)

Pharmacokinetic and Pharmacodynamic Considerations in the Design of Therapeutic Antibodies
por: Leipold, Douglas, et al.
Publicado: (2018)

Harnessing Fc/FcRn Affinity Data from Patents with Different Machine Learning Methods
por: Dumet, Christophe, et al.
Publicado: (2023)

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
por: Bien-Ly, Nga, et al.
Publicado: (2014)

Influence of Fc Modifications and IgG Subclass on Biodistribution of Humanized Antibodies Targeting L1CAM
por: Sharma, Sai Kiran, et al.
Publicado: (2022)

Novel asymmetrically engineered antibody Fc variant with superior FcγR binding affinity and specificity compared with afucosylated Fc variant
por: Mimoto, Futa, et al.
Publicado: (2013)

A novel role for the Fc receptor gamma subunit: enhancement of Fc gamma R ligand affinity
Publicado: (1996)

Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG
por: Crowley, Andrew R., et al.
Publicado: (2023)

Spatio-temporal biodistribution of (89)Zr-oxine labeled huLym-1-A-BB3z-CAR T-cells by PET imaging in a preclinical tumor model
por: Sta Maria, Naomi S., et al.
Publicado: (2021)

The genomic organization and expression pattern of the low-affinity Fc gamma receptors (FcγR) in the Göttingen minipig
por: Egli, Jerome, et al.
Publicado: (2018)

Comparison of FcRn- and pIgR-Mediated Transport in MDCK Cells by Fluorescence Confocal Microscopy
por: Jerdeva, Galina V, et al.
Publicado: (2010)

Mixed IgG Fc immune complexes exhibit blended binding profiles and refine FcR affinity estimates
por: Cyrillus Tan, Zhixin, et al.
Publicado: (2023)

Mixed IgG Fc immune complexes exhibit blended binding profiles and refine FcR affinity estimates
por: Tan, Zhixin Cyrillus, et al.
Publicado: (2023)

Toxicology and Biodistribution: The Clinical Value of Animal Biodistribution Studies
por: Silva Lima, Beatriz, et al.
Publicado: (2018)

Anti-aging technoscience & the biologization of cumulative inequality: Affinities in the biopolitics of successful aging
por: Fletcher, James Rupert
Publicado: (2020)

Identification of the low affinity receptor for immunoglobulin E on mouse mast cells and macrophages as Fc gamma RII and Fc gamma RIII
Publicado: (1992)

Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning
por: Haber, Lauric, et al.
Publicado: (2021)

Fc-Binding Ligands of Immunoglobulin G: An Overview of High Affinity Proteins and Peptides
por: Choe, Weonu, et al.
Publicado: (2016)

Human CD4(+) T-Cells: A Role for Low-Affinity Fc Receptors
por: Chauhan, Anil K.
Publicado: (2016)

Genetic Variation in Low-To-Medium-Affinity Fcγ Receptors: Functional Consequences, Disease Associations, and Opportunities for Personalized Medicine
por: Nagelkerke, Sietse Q., et al.
Publicado: (2019)

The Neonatal Fc Receptor (FcRn): A Misnomer?
por: Pyzik, Michal, et al.
Publicado: (2019)

The neonatal Fc receptor in cancer FcRn in cancer
por: Cadena Castaneda, Diana, et al.
Publicado: (2020)

Neonatal Pharmacokinetics and Biodistribution of Polymeric Nanoparticles and Effect of Surfactant
por: Xu, Nuo, et al.
Publicado: (2023)

Validation of hippocampal biomarkers of cumulative affective experience
por: Poirier, Colline, et al.
Publicado: (2019)

The high-affinity human IgG receptor Fc gamma receptor I (FcγRI) is not associated with vascular leakage of dengue
por: Mohamad Zamberi, Zaiharina, et al.
Publicado: (2015)

Effects of anchor structure and glycosylation of Fcγ receptor III on ligand binding affinity
por: Jiang, Ning, et al.
Publicado: (2016)

Evolutionary Story of the Low/Medium-Affinity IgG Fc Receptor Gene Cluster
por: Lejeune, Julien, et al.
Publicado: (2019)

Targeting the high affinity receptor, FcγRI, in autoimmune disease, neuropathy, and cancer
por: Holtrop, Tosca, et al.
Publicado: (2022)

Metastatic Melanomas Express Inhibitory Low Affinity Fc Gamma Receptor and Escape Humoral Immunity
por: Cohen-Solal, Joel F. G., et al.
Publicado: (2010)

Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation
por: Fung, Ella, et al.
Publicado: (2021)

Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling
por: Okubo, Koshu, et al.
Publicado: (2021)

Characterization of the Rabbit Neonatal Fc Receptor (FcRn) and Analyzing the Immunophenotype of the Transgenic Rabbits That Overexpresses FcRn
por: Catunda Lemos, Ana Paula, et al.
Publicado: (2012)

Ethanol Inhibits High-Affinity Immunoglobulin E Receptor (FcεRI) Signaling in Mast Cells by Suppressing the Function of FcεRI-Cholesterol Signalosome
por: Draberova, Lubica, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_bgco2qjn458ji554bicelvrnj1