Discovery and characterization of olokizumab: A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling

Interleukin-6 (IL-6) is a critical regulator of the immune system and has been widely implicated in autoimmune disease. Here, we describe the discovery and characterization of olokizumab, a humanized antibody to IL-6. Data from structural biology, cell biology and primate pharmacology demonstrate th...

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Autores principales: Shaw, Stevan, Bourne, Tim, Meier, Chris, Carrington, Bruce, Gelinas, Rich, Henry, Alistair, Popplewell, Andrew, Adams, Ralph, Baker, Terry, Rapecki, Steve, Marshall, Diane, Moore, Adrian, Neale, Helen, Lawson, Alastair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011921/
https://www.ncbi.nlm.nih.gov/pubmed/24670876
http://dx.doi.org/10.4161/mabs.28612
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author Shaw, Stevan
Bourne, Tim
Meier, Chris
Carrington, Bruce
Gelinas, Rich
Henry, Alistair
Popplewell, Andrew
Adams, Ralph
Baker, Terry
Rapecki, Steve
Marshall, Diane
Moore, Adrian
Neale, Helen
Lawson, Alastair
author_facet Shaw, Stevan
Bourne, Tim
Meier, Chris
Carrington, Bruce
Gelinas, Rich
Henry, Alistair
Popplewell, Andrew
Adams, Ralph
Baker, Terry
Rapecki, Steve
Marshall, Diane
Moore, Adrian
Neale, Helen
Lawson, Alastair
author_sort Shaw, Stevan
collection PubMed
description Interleukin-6 (IL-6) is a critical regulator of the immune system and has been widely implicated in autoimmune disease. Here, we describe the discovery and characterization of olokizumab, a humanized antibody to IL-6. Data from structural biology, cell biology and primate pharmacology demonstrate the therapeutic potential of targeting IL-6 at “Site 3”, blocking the interaction with the signaling co-receptor gp130.
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spelling pubmed-40119212015-05-01 Discovery and characterization of olokizumab: A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling Shaw, Stevan Bourne, Tim Meier, Chris Carrington, Bruce Gelinas, Rich Henry, Alistair Popplewell, Andrew Adams, Ralph Baker, Terry Rapecki, Steve Marshall, Diane Moore, Adrian Neale, Helen Lawson, Alastair MAbs Report Interleukin-6 (IL-6) is a critical regulator of the immune system and has been widely implicated in autoimmune disease. Here, we describe the discovery and characterization of olokizumab, a humanized antibody to IL-6. Data from structural biology, cell biology and primate pharmacology demonstrate the therapeutic potential of targeting IL-6 at “Site 3”, blocking the interaction with the signaling co-receptor gp130. Landes Bioscience 2014-05-01 2014-04-02 /pmc/articles/PMC4011921/ /pubmed/24670876 http://dx.doi.org/10.4161/mabs.28612 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by/3.0/ This is an open-access article licensed under a Creative Commons Attribution 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Report
Shaw, Stevan
Bourne, Tim
Meier, Chris
Carrington, Bruce
Gelinas, Rich
Henry, Alistair
Popplewell, Andrew
Adams, Ralph
Baker, Terry
Rapecki, Steve
Marshall, Diane
Moore, Adrian
Neale, Helen
Lawson, Alastair
Discovery and characterization of olokizumab: A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling
title Discovery and characterization of olokizumab: A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling
title_full Discovery and characterization of olokizumab: A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling
title_fullStr Discovery and characterization of olokizumab: A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling
title_full_unstemmed Discovery and characterization of olokizumab: A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling
title_short Discovery and characterization of olokizumab: A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling
title_sort discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011921/
https://www.ncbi.nlm.nih.gov/pubmed/24670876
http://dx.doi.org/10.4161/mabs.28612
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