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Association of LRP5 genotypes with osteoporosis in Tunisian post-menopausal women

BACKGROUND: Osteoporosis is a highly heritable trait. Among the genes associated with bone mineral density (BMD), the low-density lipoprotein receptor-related protein 5 gene (LRP5) has been consistently identified in Caucasians. However LRP5 contribution to osteoporosis in populations of other ethni...

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Autores principales: Sassi, Rim, Sahli, Hela, Souissi, Chiraz, El Mahmoudi, Hejer, Zouari, Bechir, Ben Ammar ElGaaied, Amel, Sellami, Slaheddine, Ferrari, Serge Livio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012028/
https://www.ncbi.nlm.nih.gov/pubmed/24885293
http://dx.doi.org/10.1186/1471-2474-15-144
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author Sassi, Rim
Sahli, Hela
Souissi, Chiraz
El Mahmoudi, Hejer
Zouari, Bechir
Ben Ammar ElGaaied, Amel
Sellami, Slaheddine
Ferrari, Serge Livio
author_facet Sassi, Rim
Sahli, Hela
Souissi, Chiraz
El Mahmoudi, Hejer
Zouari, Bechir
Ben Ammar ElGaaied, Amel
Sellami, Slaheddine
Ferrari, Serge Livio
author_sort Sassi, Rim
collection PubMed
description BACKGROUND: Osteoporosis is a highly heritable trait. Among the genes associated with bone mineral density (BMD), the low-density lipoprotein receptor-related protein 5 gene (LRP5) has been consistently identified in Caucasians. However LRP5 contribution to osteoporosis in populations of other ethnicities remains poorly known. METHODS: To determine whether LRP5 polymorphisms Ala1330Val and Val667Met are associated with BMD in North Africans, these genotypes were analyzed in 566 post-menopausal Tunisian women with mean age of 59.5 ± 7.7 years, of which 59.1% have low bone mass (T-score < −1 at spine or hip). RESULTS: In post-menopausal Tunisian women, 1330Val was weakly associated with reduced BMD T-score at lumbar spine (p = 0.047) but not femur neck. Moreover, the TT/TC genotypes tended to be more frequent in women with osteopenia and osteoporosis than in women with normal BMD (p = 0.066). Adjusting for body size and other potential confounders, LRP5 genotypes were no longer significantly associated with aBMD at any site. CONCLUSIONS: The less common Val667Met polymorphism showed no association with osteoporosis. The Ala1330Val polymorphism is weakly associated with lower lumbar spine bone density and osteopenia/osteoporosis in postmenopausal Tunisian women. These observations expand our knowledge about the contribution of LRP5 genetic variation to osteoporosis risk in populations of diverse ethnic origin.
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spelling pubmed-40120282014-05-08 Association of LRP5 genotypes with osteoporosis in Tunisian post-menopausal women Sassi, Rim Sahli, Hela Souissi, Chiraz El Mahmoudi, Hejer Zouari, Bechir Ben Ammar ElGaaied, Amel Sellami, Slaheddine Ferrari, Serge Livio BMC Musculoskelet Disord Research Article BACKGROUND: Osteoporosis is a highly heritable trait. Among the genes associated with bone mineral density (BMD), the low-density lipoprotein receptor-related protein 5 gene (LRP5) has been consistently identified in Caucasians. However LRP5 contribution to osteoporosis in populations of other ethnicities remains poorly known. METHODS: To determine whether LRP5 polymorphisms Ala1330Val and Val667Met are associated with BMD in North Africans, these genotypes were analyzed in 566 post-menopausal Tunisian women with mean age of 59.5 ± 7.7 years, of which 59.1% have low bone mass (T-score < −1 at spine or hip). RESULTS: In post-menopausal Tunisian women, 1330Val was weakly associated with reduced BMD T-score at lumbar spine (p = 0.047) but not femur neck. Moreover, the TT/TC genotypes tended to be more frequent in women with osteopenia and osteoporosis than in women with normal BMD (p = 0.066). Adjusting for body size and other potential confounders, LRP5 genotypes were no longer significantly associated with aBMD at any site. CONCLUSIONS: The less common Val667Met polymorphism showed no association with osteoporosis. The Ala1330Val polymorphism is weakly associated with lower lumbar spine bone density and osteopenia/osteoporosis in postmenopausal Tunisian women. These observations expand our knowledge about the contribution of LRP5 genetic variation to osteoporosis risk in populations of diverse ethnic origin. BioMed Central 2014-04-30 /pmc/articles/PMC4012028/ /pubmed/24885293 http://dx.doi.org/10.1186/1471-2474-15-144 Text en Copyright © 2014 Sassi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
Sassi, Rim
Sahli, Hela
Souissi, Chiraz
El Mahmoudi, Hejer
Zouari, Bechir
Ben Ammar ElGaaied, Amel
Sellami, Slaheddine
Ferrari, Serge Livio
Association of LRP5 genotypes with osteoporosis in Tunisian post-menopausal women
title Association of LRP5 genotypes with osteoporosis in Tunisian post-menopausal women
title_full Association of LRP5 genotypes with osteoporosis in Tunisian post-menopausal women
title_fullStr Association of LRP5 genotypes with osteoporosis in Tunisian post-menopausal women
title_full_unstemmed Association of LRP5 genotypes with osteoporosis in Tunisian post-menopausal women
title_short Association of LRP5 genotypes with osteoporosis in Tunisian post-menopausal women
title_sort association of lrp5 genotypes with osteoporosis in tunisian post-menopausal women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012028/
https://www.ncbi.nlm.nih.gov/pubmed/24885293
http://dx.doi.org/10.1186/1471-2474-15-144
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