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Seroprevalence of Lawsonia intracellularis antibodies in intensive pig farms in China

BACKGROUND: Porcine proliferative enteropathy caused by Lawsonia intracellularis (L. intracellularis) is a major concern to the pig industry worldwide. Although 8.3 billion pigs are produced each year in China, few reports on the prevalence of L.intracellularis infection are available. The aim of th...

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Autores principales: Wu, Zongxue, Ling, Yong, Tian, Deyu, Pan, Qing, Heegaard, Peter M H, He, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012184/
https://www.ncbi.nlm.nih.gov/pubmed/24774304
http://dx.doi.org/10.1186/1746-6148-10-100
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author Wu, Zongxue
Ling, Yong
Tian, Deyu
Pan, Qing
Heegaard, Peter M H
He, Cheng
author_facet Wu, Zongxue
Ling, Yong
Tian, Deyu
Pan, Qing
Heegaard, Peter M H
He, Cheng
author_sort Wu, Zongxue
collection PubMed
description BACKGROUND: Porcine proliferative enteropathy caused by Lawsonia intracellularis (L. intracellularis) is a major concern to the pig industry worldwide. Although 8.3 billion pigs are produced each year in China, few reports on the prevalence of L.intracellularis infection are available. The aim of the current study was to estimate the seroprevalence of L. intracellularis antibodies in intensive pig farms in China. RESULTS: A total of 1060 serum samples were collected from 14 commercial pig farms located throughout China. Animals from all age groups were sampled including pre-weaning piglets, weaners, fattening pigs, adult sows and boars. Antibodies against L. intracellularis were detected using a specific blocking ELISA. Of the 1060 serum samples, 602 were identified as positive using the ELISA test. The apparent seroprevalence of L. intracellularis seropositivity was 57% (95% CI 50 to 64%). The true prevalence (that is, prevalence corrected for the imperfect sensitivity and specificity of the testing method) was 77% (95% CI 70 to 83%). CONCLUSIONS: The highest true prevalence was observed in sows and boars, suggesting that within a herd these stock classes are a reservoir for infection. The prevalence of L. intracellularis seropositivity in local breed pigs was significantly less than that in imported breeds. A higher seroprevalence was found in pigs in herds in Central and Northern China, which may correspond to the greater use of the intensive production systems in these areas. We conclude that L. intracellularis is widely prevalent in commercial pigs in China.
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spelling pubmed-40121842014-05-08 Seroprevalence of Lawsonia intracellularis antibodies in intensive pig farms in China Wu, Zongxue Ling, Yong Tian, Deyu Pan, Qing Heegaard, Peter M H He, Cheng BMC Vet Res Research Article BACKGROUND: Porcine proliferative enteropathy caused by Lawsonia intracellularis (L. intracellularis) is a major concern to the pig industry worldwide. Although 8.3 billion pigs are produced each year in China, few reports on the prevalence of L.intracellularis infection are available. The aim of the current study was to estimate the seroprevalence of L. intracellularis antibodies in intensive pig farms in China. RESULTS: A total of 1060 serum samples were collected from 14 commercial pig farms located throughout China. Animals from all age groups were sampled including pre-weaning piglets, weaners, fattening pigs, adult sows and boars. Antibodies against L. intracellularis were detected using a specific blocking ELISA. Of the 1060 serum samples, 602 were identified as positive using the ELISA test. The apparent seroprevalence of L. intracellularis seropositivity was 57% (95% CI 50 to 64%). The true prevalence (that is, prevalence corrected for the imperfect sensitivity and specificity of the testing method) was 77% (95% CI 70 to 83%). CONCLUSIONS: The highest true prevalence was observed in sows and boars, suggesting that within a herd these stock classes are a reservoir for infection. The prevalence of L. intracellularis seropositivity in local breed pigs was significantly less than that in imported breeds. A higher seroprevalence was found in pigs in herds in Central and Northern China, which may correspond to the greater use of the intensive production systems in these areas. We conclude that L. intracellularis is widely prevalent in commercial pigs in China. BioMed Central 2014-04-28 /pmc/articles/PMC4012184/ /pubmed/24774304 http://dx.doi.org/10.1186/1746-6148-10-100 Text en Copyright © 2014 Wu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
Wu, Zongxue
Ling, Yong
Tian, Deyu
Pan, Qing
Heegaard, Peter M H
He, Cheng
Seroprevalence of Lawsonia intracellularis antibodies in intensive pig farms in China
title Seroprevalence of Lawsonia intracellularis antibodies in intensive pig farms in China
title_full Seroprevalence of Lawsonia intracellularis antibodies in intensive pig farms in China
title_fullStr Seroprevalence of Lawsonia intracellularis antibodies in intensive pig farms in China
title_full_unstemmed Seroprevalence of Lawsonia intracellularis antibodies in intensive pig farms in China
title_short Seroprevalence of Lawsonia intracellularis antibodies in intensive pig farms in China
title_sort seroprevalence of lawsonia intracellularis antibodies in intensive pig farms in china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012184/
https://www.ncbi.nlm.nih.gov/pubmed/24774304
http://dx.doi.org/10.1186/1746-6148-10-100
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