Structural basis for pure antagonism of integrin αVβ3 by a high affinity form of fibronectin

Integrins are important therapeutic targets. However, current RGD-based anti-integrin drugs are also partial agonists, inducing conformational changes that trigger potentially fatal immune reactions and paradoxical cell adhesion. Here we describe the first crystal structure of αVβ3 bound to a physio...

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Detalles Bibliográficos
Autores principales: Van Agthoven, Johannes F., Xiong, Jian-Ping, Alonso, José Luis, Rui, Xianliang, Adair, Brian D., Goodman, Simon L., Arnaout, M. Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012256/
https://www.ncbi.nlm.nih.gov/pubmed/24658351
http://dx.doi.org/10.1038/nsmb.2797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012256/
https://www.ncbi.nlm.nih.gov/pubmed/24658351
http://dx.doi.org/10.1038/nsmb.2797

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