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A snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study
Few biomarkers have been known that can easily measure clinical conditions in mental illnesses such as schizophrenia. Capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS) is a new method that can measure ionized and low-molecular-weight metabolites. To explore global metabolomic alt...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012283/ https://www.ncbi.nlm.nih.gov/pubmed/24713860 http://dx.doi.org/10.1038/tp.2014.19 |
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author | Koike, S Bundo, M Iwamoto, K Suga, M Kuwabara, H Ohashi, Y Shinoda, K Takano, Y Iwashiro, N Satomura, Y Nagai, T Natsubori, T Tada, M Yamasue, H Kasai, K |
author_facet | Koike, S Bundo, M Iwamoto, K Suga, M Kuwabara, H Ohashi, Y Shinoda, K Takano, Y Iwashiro, N Satomura, Y Nagai, T Natsubori, T Tada, M Yamasue, H Kasai, K |
author_sort | Koike, S |
collection | PubMed |
description | Few biomarkers have been known that can easily measure clinical conditions in mental illnesses such as schizophrenia. Capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS) is a new method that can measure ionized and low-molecular-weight metabolites. To explore global metabolomic alterations that characterize the onset of schizophrenia and identify biomarkers, we profiled the relative and absolute concentrations of the plasma metabolites from 30 patients with first-episode schizophrenia (FESZ, four drug-naïve samples), 38 healthy controls and 15 individuals with autism spectrum disorders using CE-TOFMS. Five metabolites had robust changes (increased creatine and decreased betaine, nonanoic acid, benzoic acid and perillic acid) in two independent sample sets. Altered levels of these metabolites are consistent with well-known hypotheses regarding abnormalities of the homocysteine metabolism, creatine kinase-emia and oxidative stress. Although it should be considered that most patients with FESZ received medication, these metabolites are candidate biomarkers to improve the determination of diagnosis, severity and clinical stages, especially for FESZ. |
format | Online Article Text |
id | pubmed-4012283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-40122832014-05-07 A snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study Koike, S Bundo, M Iwamoto, K Suga, M Kuwabara, H Ohashi, Y Shinoda, K Takano, Y Iwashiro, N Satomura, Y Nagai, T Natsubori, T Tada, M Yamasue, H Kasai, K Transl Psychiatry Original Article Few biomarkers have been known that can easily measure clinical conditions in mental illnesses such as schizophrenia. Capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS) is a new method that can measure ionized and low-molecular-weight metabolites. To explore global metabolomic alterations that characterize the onset of schizophrenia and identify biomarkers, we profiled the relative and absolute concentrations of the plasma metabolites from 30 patients with first-episode schizophrenia (FESZ, four drug-naïve samples), 38 healthy controls and 15 individuals with autism spectrum disorders using CE-TOFMS. Five metabolites had robust changes (increased creatine and decreased betaine, nonanoic acid, benzoic acid and perillic acid) in two independent sample sets. Altered levels of these metabolites are consistent with well-known hypotheses regarding abnormalities of the homocysteine metabolism, creatine kinase-emia and oxidative stress. Although it should be considered that most patients with FESZ received medication, these metabolites are candidate biomarkers to improve the determination of diagnosis, severity and clinical stages, especially for FESZ. Nature Publishing Group 2014-04 2014-04-08 /pmc/articles/PMC4012283/ /pubmed/24713860 http://dx.doi.org/10.1038/tp.2014.19 Text en Copyright © 2014 Macmillan Publishers Limited http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Original Article Koike, S Bundo, M Iwamoto, K Suga, M Kuwabara, H Ohashi, Y Shinoda, K Takano, Y Iwashiro, N Satomura, Y Nagai, T Natsubori, T Tada, M Yamasue, H Kasai, K A snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study |
title | A snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study |
title_full | A snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study |
title_fullStr | A snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study |
title_full_unstemmed | A snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study |
title_short | A snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study |
title_sort | snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012283/ https://www.ncbi.nlm.nih.gov/pubmed/24713860 http://dx.doi.org/10.1038/tp.2014.19 |
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