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Grand-paternal age and the development of autism-like symptoms in mice progeny
Advanced paternal age (APA) contributes to the risk of autism spectrum disorders (ASDs) in children. In this study, we used a mouse model to investigate the effects of APA on behavioral features related to autistic syndromes (that is, social deficits, communication impairments and stereotypic/repeti...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012289/ https://www.ncbi.nlm.nih.gov/pubmed/24780920 http://dx.doi.org/10.1038/tp.2014.27 |
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author | Sampino, S Juszczak, G R Zacchini, F Swiergiel, A H Modlinski, J A Loi, P Ptak, G E |
author_facet | Sampino, S Juszczak, G R Zacchini, F Swiergiel, A H Modlinski, J A Loi, P Ptak, G E |
author_sort | Sampino, S |
collection | PubMed |
description | Advanced paternal age (APA) contributes to the risk of autism spectrum disorders (ASDs) in children. In this study, we used a mouse model to investigate the effects of APA on behavioral features related to autistic syndromes (that is, social deficits, communication impairments and stereotypic/repetitive behaviors). We also examined whether such effects are transmitted across generations. To do this, males aged 15 months (APA) and 4 months (control) were bred with 4-month-old females, and the resulting offspring (F1) and their progeny (F2; conceived by 4-month-old parents) were tested for the presence and severity of ASD-like behaviors. Our results indicate that APA resulted in offspring that displayed distinctive symptoms of ASD. We found that both F1 conceived from old fathers and F2 derived from old grandfathers displayed increased ultrasound vocalization (USV) activity, decreased sociability, increased grooming activity and increased anxiety-like responses. Moreover, such abnormalities were partially transmitted to the second generation of mice, having APA grandfathers. In conclusion, our study suggests that the risk of ASD could develop over generations, consistent with heritable mutations and/or epigenetic alterations associated with APA. |
format | Online Article Text |
id | pubmed-4012289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-40122892014-05-07 Grand-paternal age and the development of autism-like symptoms in mice progeny Sampino, S Juszczak, G R Zacchini, F Swiergiel, A H Modlinski, J A Loi, P Ptak, G E Transl Psychiatry Original Article Advanced paternal age (APA) contributes to the risk of autism spectrum disorders (ASDs) in children. In this study, we used a mouse model to investigate the effects of APA on behavioral features related to autistic syndromes (that is, social deficits, communication impairments and stereotypic/repetitive behaviors). We also examined whether such effects are transmitted across generations. To do this, males aged 15 months (APA) and 4 months (control) were bred with 4-month-old females, and the resulting offspring (F1) and their progeny (F2; conceived by 4-month-old parents) were tested for the presence and severity of ASD-like behaviors. Our results indicate that APA resulted in offspring that displayed distinctive symptoms of ASD. We found that both F1 conceived from old fathers and F2 derived from old grandfathers displayed increased ultrasound vocalization (USV) activity, decreased sociability, increased grooming activity and increased anxiety-like responses. Moreover, such abnormalities were partially transmitted to the second generation of mice, having APA grandfathers. In conclusion, our study suggests that the risk of ASD could develop over generations, consistent with heritable mutations and/or epigenetic alterations associated with APA. Nature Publishing Group 2014-04 2014-04-29 /pmc/articles/PMC4012289/ /pubmed/24780920 http://dx.doi.org/10.1038/tp.2014.27 Text en Copyright © 2014 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Original Article Sampino, S Juszczak, G R Zacchini, F Swiergiel, A H Modlinski, J A Loi, P Ptak, G E Grand-paternal age and the development of autism-like symptoms in mice progeny |
title | Grand-paternal age and the development of autism-like symptoms in mice progeny |
title_full | Grand-paternal age and the development of autism-like symptoms in mice progeny |
title_fullStr | Grand-paternal age and the development of autism-like symptoms in mice progeny |
title_full_unstemmed | Grand-paternal age and the development of autism-like symptoms in mice progeny |
title_short | Grand-paternal age and the development of autism-like symptoms in mice progeny |
title_sort | grand-paternal age and the development of autism-like symptoms in mice progeny |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012289/ https://www.ncbi.nlm.nih.gov/pubmed/24780920 http://dx.doi.org/10.1038/tp.2014.27 |
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