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Effects of EPHX1 and CYP3A4 polymorphisms on carbamazepine metabolism in epileptic patients

BACKGROUND: The aim of this study was to investigate the effect of two genetic polymorphisms in the coding regions (exon 3 and exon 4) of the EPHX1 gene, ie, 337T>C and 416A>G, respectively, on the metabolism of carbamazepine (CBZ) 10,11-epoxide (the active metabolite of CBZ) by evaluating the...

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Detalles Bibliográficos
Autores principales:	Caruso, Antonietta, Bellia, Chiara, Pivetti, Alessia, Agnello, Luisa, Bazza, Federica, Scazzone, Concetta, Bivona, Giulia, Lo Sasso, Bruna, Ciaccio, Marcello
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012346/ https://www.ncbi.nlm.nih.gov/pubmed/24817818 http://dx.doi.org/10.2147/PGPM.S55548

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