Cladieunicellins M–Q, New Eunicellins from Cladiella sp.

Five new 7α-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M–Q (1–5), were isolated from a Formosan octocoral Cladiella sp. The structures of 1–5 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxic...

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Autores principales: Chen, Tsung-Hung, Chen, Wu-Fu, Wen, Zhi-Hong, Lu, Mei-Chin, Wang, Wei-Hsien, Li, Jan-Jung, Wu, Yang-Chang, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012457/
https://www.ncbi.nlm.nih.gov/pubmed/24717524
http://dx.doi.org/10.3390/md12042144
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author Chen, Tsung-Hung
Chen, Wu-Fu
Wen, Zhi-Hong
Lu, Mei-Chin
Wang, Wei-Hsien
Li, Jan-Jung
Wu, Yang-Chang
Sung, Ping-Jyun
author_facet Chen, Tsung-Hung
Chen, Wu-Fu
Wen, Zhi-Hong
Lu, Mei-Chin
Wang, Wei-Hsien
Li, Jan-Jung
Wu, Yang-Chang
Sung, Ping-Jyun
author_sort Chen, Tsung-Hung
collection PubMed
description Five new 7α-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M–Q (1–5), were isolated from a Formosan octocoral Cladiella sp. The structures of 1–5 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1–5 against the human leukemia Molt 4 and HL 60 is also described. Among them, compounds 1, 3 and 5 exhibited moderate cytotoxicity toward Molt 4 cells with IC(50) values 16.43, 14.17 and 15.55 μM, respectively. Preliminary SAR (structure activity relationship) information was obtained from these compounds and their analogues.
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spelling pubmed-40124572014-05-07 Cladieunicellins M–Q, New Eunicellins from Cladiella sp. Chen, Tsung-Hung Chen, Wu-Fu Wen, Zhi-Hong Lu, Mei-Chin Wang, Wei-Hsien Li, Jan-Jung Wu, Yang-Chang Sung, Ping-Jyun Mar Drugs Communication Five new 7α-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M–Q (1–5), were isolated from a Formosan octocoral Cladiella sp. The structures of 1–5 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1–5 against the human leukemia Molt 4 and HL 60 is also described. Among them, compounds 1, 3 and 5 exhibited moderate cytotoxicity toward Molt 4 cells with IC(50) values 16.43, 14.17 and 15.55 μM, respectively. Preliminary SAR (structure activity relationship) information was obtained from these compounds and their analogues. MDPI 2014-04-08 /pmc/articles/PMC4012457/ /pubmed/24717524 http://dx.doi.org/10.3390/md12042144 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Chen, Tsung-Hung
Chen, Wu-Fu
Wen, Zhi-Hong
Lu, Mei-Chin
Wang, Wei-Hsien
Li, Jan-Jung
Wu, Yang-Chang
Sung, Ping-Jyun
Cladieunicellins M–Q, New Eunicellins from Cladiella sp.
title Cladieunicellins M–Q, New Eunicellins from Cladiella sp.
title_full Cladieunicellins M–Q, New Eunicellins from Cladiella sp.
title_fullStr Cladieunicellins M–Q, New Eunicellins from Cladiella sp.
title_full_unstemmed Cladieunicellins M–Q, New Eunicellins from Cladiella sp.
title_short Cladieunicellins M–Q, New Eunicellins from Cladiella sp.
title_sort cladieunicellins m–q, new eunicellins from cladiella sp.
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012457/
https://www.ncbi.nlm.nih.gov/pubmed/24717524
http://dx.doi.org/10.3390/md12042144
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