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Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.
A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012465/ https://www.ncbi.nlm.nih.gov/pubmed/24705502 http://dx.doi.org/10.3390/md12042054 |
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author | Kim, Hiyoung Kim, Kwang-Jin Yeon, Jeong-Tae Kim, Seong Hwan Won, Dong Hwan Choi, Hyukjae Nam, Sang-Jip Son, Young-Jin Kang, Heonjoong |
author_facet | Kim, Hiyoung Kim, Kwang-Jin Yeon, Jeong-Tae Kim, Seong Hwan Won, Dong Hwan Choi, Hyukjae Nam, Sang-Jip Son, Young-Jin Kang, Heonjoong |
author_sort | Kim, Hiyoung |
collection | PubMed |
description | A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against RANKL-induced osteoclast differentiation at 10 μM while placotylene B (2) did not show any significant activity up to 100 μM, respectively. |
format | Online Article Text |
id | pubmed-4012465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-40124652014-05-07 Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp. Kim, Hiyoung Kim, Kwang-Jin Yeon, Jeong-Tae Kim, Seong Hwan Won, Dong Hwan Choi, Hyukjae Nam, Sang-Jip Son, Young-Jin Kang, Heonjoong Mar Drugs Article A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against RANKL-induced osteoclast differentiation at 10 μM while placotylene B (2) did not show any significant activity up to 100 μM, respectively. MDPI 2014-04-03 /pmc/articles/PMC4012465/ /pubmed/24705502 http://dx.doi.org/10.3390/md12042054 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Kim, Hiyoung Kim, Kwang-Jin Yeon, Jeong-Tae Kim, Seong Hwan Won, Dong Hwan Choi, Hyukjae Nam, Sang-Jip Son, Young-Jin Kang, Heonjoong Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp. |
title | Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp. |
title_full | Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp. |
title_fullStr | Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp. |
title_full_unstemmed | Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp. |
title_short | Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp. |
title_sort | placotylene a, an inhibitor of the receptor activator of nuclear factor-κb ligand-induced osteoclast differentiation, from a korean sponge placospongia sp. |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012465/ https://www.ncbi.nlm.nih.gov/pubmed/24705502 http://dx.doi.org/10.3390/md12042054 |
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