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Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.

A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were...

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Autores principales: Kim, Hiyoung, Kim, Kwang-Jin, Yeon, Jeong-Tae, Kim, Seong Hwan, Won, Dong Hwan, Choi, Hyukjae, Nam, Sang-Jip, Son, Young-Jin, Kang, Heonjoong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012465/
https://www.ncbi.nlm.nih.gov/pubmed/24705502
http://dx.doi.org/10.3390/md12042054
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author Kim, Hiyoung
Kim, Kwang-Jin
Yeon, Jeong-Tae
Kim, Seong Hwan
Won, Dong Hwan
Choi, Hyukjae
Nam, Sang-Jip
Son, Young-Jin
Kang, Heonjoong
author_facet Kim, Hiyoung
Kim, Kwang-Jin
Yeon, Jeong-Tae
Kim, Seong Hwan
Won, Dong Hwan
Choi, Hyukjae
Nam, Sang-Jip
Son, Young-Jin
Kang, Heonjoong
author_sort Kim, Hiyoung
collection PubMed
description A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against RANKL-induced osteoclast differentiation at 10 μM while placotylene B (2) did not show any significant activity up to 100 μM, respectively.
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spelling pubmed-40124652014-05-07 Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp. Kim, Hiyoung Kim, Kwang-Jin Yeon, Jeong-Tae Kim, Seong Hwan Won, Dong Hwan Choi, Hyukjae Nam, Sang-Jip Son, Young-Jin Kang, Heonjoong Mar Drugs Article A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against RANKL-induced osteoclast differentiation at 10 μM while placotylene B (2) did not show any significant activity up to 100 μM, respectively. MDPI 2014-04-03 /pmc/articles/PMC4012465/ /pubmed/24705502 http://dx.doi.org/10.3390/md12042054 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kim, Hiyoung
Kim, Kwang-Jin
Yeon, Jeong-Tae
Kim, Seong Hwan
Won, Dong Hwan
Choi, Hyukjae
Nam, Sang-Jip
Son, Young-Jin
Kang, Heonjoong
Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.
title Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.
title_full Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.
title_fullStr Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.
title_full_unstemmed Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.
title_short Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.
title_sort placotylene a, an inhibitor of the receptor activator of nuclear factor-κb ligand-induced osteoclast differentiation, from a korean sponge placospongia sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012465/
https://www.ncbi.nlm.nih.gov/pubmed/24705502
http://dx.doi.org/10.3390/md12042054
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