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Meningiomas occurring during long-term survival after treatment for childhood cancer
Childhood cancer is rare but improvements in treatment over the past five decades have resulted in a cohort of more than 30,000 long-term survivors of childhood cancer in the UK with more added annually. These long-term survivors are at risk of late effects of cancer treatment which replace original...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012666/ https://www.ncbi.nlm.nih.gov/pubmed/25057388 http://dx.doi.org/10.1177/2054270414524567 |
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author | Sugden, Elaine Taylor, Aliki Pretorius, Pieter Kennedy, Colin Bhangoo, Ranj |
author_facet | Sugden, Elaine Taylor, Aliki Pretorius, Pieter Kennedy, Colin Bhangoo, Ranj |
author_sort | Sugden, Elaine |
collection | PubMed |
description | Childhood cancer is rare but improvements in treatment over the past five decades have resulted in a cohort of more than 30,000 long-term survivors of childhood cancer in the UK with more added annually. These long-term survivors are at risk of late effects of cancer treatment which replace original tumour recurrence as the leading cause of premature death. Second neoplasms are a particular risk and in the central nervous system meningiomas occur increasingly with increased radiation dose to central nervous system tissue and length of time after exposure, resulting in a 500-fold increase above that expected in the normal population by 40 years of follow up. This multidisciplinary author group and others met to discuss the issue. Our pooled information, and consensus that screening should only follow symptoms, was published online by the Royal College of Radiologists in 2013. We outline here the current knowledge and management of these neoplasms secondary to childhood cancer treatment. |
format | Online Article Text |
id | pubmed-4012666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-40126662014-07-23 Meningiomas occurring during long-term survival after treatment for childhood cancer Sugden, Elaine Taylor, Aliki Pretorius, Pieter Kennedy, Colin Bhangoo, Ranj JRSM Open Clinical Reviews Childhood cancer is rare but improvements in treatment over the past five decades have resulted in a cohort of more than 30,000 long-term survivors of childhood cancer in the UK with more added annually. These long-term survivors are at risk of late effects of cancer treatment which replace original tumour recurrence as the leading cause of premature death. Second neoplasms are a particular risk and in the central nervous system meningiomas occur increasingly with increased radiation dose to central nervous system tissue and length of time after exposure, resulting in a 500-fold increase above that expected in the normal population by 40 years of follow up. This multidisciplinary author group and others met to discuss the issue. Our pooled information, and consensus that screening should only follow symptoms, was published online by the Royal College of Radiologists in 2013. We outline here the current knowledge and management of these neoplasms secondary to childhood cancer treatment. SAGE Publications 2014-03-12 /pmc/articles/PMC4012666/ /pubmed/25057388 http://dx.doi.org/10.1177/2054270414524567 Text en © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm). |
spellingShingle | Clinical Reviews Sugden, Elaine Taylor, Aliki Pretorius, Pieter Kennedy, Colin Bhangoo, Ranj Meningiomas occurring during long-term survival after treatment for childhood cancer |
title | Meningiomas occurring during long-term survival after treatment for childhood cancer |
title_full | Meningiomas occurring during long-term survival after treatment for childhood cancer |
title_fullStr | Meningiomas occurring during long-term survival after treatment for childhood cancer |
title_full_unstemmed | Meningiomas occurring during long-term survival after treatment for childhood cancer |
title_short | Meningiomas occurring during long-term survival after treatment for childhood cancer |
title_sort | meningiomas occurring during long-term survival after treatment for childhood cancer |
topic | Clinical Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012666/ https://www.ncbi.nlm.nih.gov/pubmed/25057388 http://dx.doi.org/10.1177/2054270414524567 |
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