Antibodies reacting with Simian Virus 40 capsid protein mimotopes in serum samples from patients affected by uveal melanoma

The uveal melanoma (UM) is the most common human intraocular tumour. Simian Virus 40 (SV-40) is a small DNA tumor virus detected in some malignancies, including the cutaneous melanoma. In this study an indirect ELISA using synthetic peptides that mimic SV-40 antigens, was employed to detect antibodi...

Descripción completa

Detalles Bibliográficos
Autores principales: Bononi, Ilaria, Perri, Paolo, Begnardi, Alice, Martini, Alessandra, Mazzoni, Elisa, Bosi, Silvia, Pietrobon, Silvia, Sebastiani, Adolfo, Tognon, Mauro, Martini, Fernanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012707/
https://www.ncbi.nlm.nih.gov/pubmed/24886631
http://dx.doi.org/10.1186/1756-8722-7-38
_version_ 1782314959449882624
author Bononi, Ilaria
Perri, Paolo
Begnardi, Alice
Martini, Alessandra
Mazzoni, Elisa
Bosi, Silvia
Pietrobon, Silvia
Sebastiani, Adolfo
Tognon, Mauro
Martini, Fernanda
author_facet Bononi, Ilaria
Perri, Paolo
Begnardi, Alice
Martini, Alessandra
Mazzoni, Elisa
Bosi, Silvia
Pietrobon, Silvia
Sebastiani, Adolfo
Tognon, Mauro
Martini, Fernanda
author_sort Bononi, Ilaria
collection PubMed
description The uveal melanoma (UM) is the most common human intraocular tumour. Simian Virus 40 (SV-40) is a small DNA tumor virus detected in some malignancies, including the cutaneous melanoma. In this study an indirect ELISA using synthetic peptides that mimic SV-40 antigens, was employed to detect antibodies against SV-40 in serum samples from UM patients. Our report indicates a significant higher prevalence of antibodies against SV-40 capsid protein antigens in serum samples from UM patients compared to controls. Our data suggest an association between UM and SV-40, indicating that patients affected by uveal melanoma tested SV-40-positive could be treated by innovative therapies.
format Online
Article
Text
id pubmed-4012707
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-40127072014-05-08 Antibodies reacting with Simian Virus 40 capsid protein mimotopes in serum samples from patients affected by uveal melanoma Bononi, Ilaria Perri, Paolo Begnardi, Alice Martini, Alessandra Mazzoni, Elisa Bosi, Silvia Pietrobon, Silvia Sebastiani, Adolfo Tognon, Mauro Martini, Fernanda J Hematol Oncol Letter to the Editor The uveal melanoma (UM) is the most common human intraocular tumour. Simian Virus 40 (SV-40) is a small DNA tumor virus detected in some malignancies, including the cutaneous melanoma. In this study an indirect ELISA using synthetic peptides that mimic SV-40 antigens, was employed to detect antibodies against SV-40 in serum samples from UM patients. Our report indicates a significant higher prevalence of antibodies against SV-40 capsid protein antigens in serum samples from UM patients compared to controls. Our data suggest an association between UM and SV-40, indicating that patients affected by uveal melanoma tested SV-40-positive could be treated by innovative therapies. BioMed Central 2014-04-29 /pmc/articles/PMC4012707/ /pubmed/24886631 http://dx.doi.org/10.1186/1756-8722-7-38 Text en Copyright © 2014 Bononi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Bononi, Ilaria
Perri, Paolo
Begnardi, Alice
Martini, Alessandra
Mazzoni, Elisa
Bosi, Silvia
Pietrobon, Silvia
Sebastiani, Adolfo
Tognon, Mauro
Martini, Fernanda
Antibodies reacting with Simian Virus 40 capsid protein mimotopes in serum samples from patients affected by uveal melanoma
title Antibodies reacting with Simian Virus 40 capsid protein mimotopes in serum samples from patients affected by uveal melanoma
title_full Antibodies reacting with Simian Virus 40 capsid protein mimotopes in serum samples from patients affected by uveal melanoma
title_fullStr Antibodies reacting with Simian Virus 40 capsid protein mimotopes in serum samples from patients affected by uveal melanoma
title_full_unstemmed Antibodies reacting with Simian Virus 40 capsid protein mimotopes in serum samples from patients affected by uveal melanoma
title_short Antibodies reacting with Simian Virus 40 capsid protein mimotopes in serum samples from patients affected by uveal melanoma
title_sort antibodies reacting with simian virus 40 capsid protein mimotopes in serum samples from patients affected by uveal melanoma
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012707/
https://www.ncbi.nlm.nih.gov/pubmed/24886631
http://dx.doi.org/10.1186/1756-8722-7-38
work_keys_str_mv AT bononiilaria antibodiesreactingwithsimianvirus40capsidproteinmimotopesinserumsamplesfrompatientsaffectedbyuvealmelanoma
AT perripaolo antibodiesreactingwithsimianvirus40capsidproteinmimotopesinserumsamplesfrompatientsaffectedbyuvealmelanoma
AT begnardialice antibodiesreactingwithsimianvirus40capsidproteinmimotopesinserumsamplesfrompatientsaffectedbyuvealmelanoma
AT martinialessandra antibodiesreactingwithsimianvirus40capsidproteinmimotopesinserumsamplesfrompatientsaffectedbyuvealmelanoma
AT mazzonielisa antibodiesreactingwithsimianvirus40capsidproteinmimotopesinserumsamplesfrompatientsaffectedbyuvealmelanoma
AT bosisilvia antibodiesreactingwithsimianvirus40capsidproteinmimotopesinserumsamplesfrompatientsaffectedbyuvealmelanoma
AT pietrobonsilvia antibodiesreactingwithsimianvirus40capsidproteinmimotopesinserumsamplesfrompatientsaffectedbyuvealmelanoma
AT sebastianiadolfo antibodiesreactingwithsimianvirus40capsidproteinmimotopesinserumsamplesfrompatientsaffectedbyuvealmelanoma
AT tognonmauro antibodiesreactingwithsimianvirus40capsidproteinmimotopesinserumsamplesfrompatientsaffectedbyuvealmelanoma
AT martinifernanda antibodiesreactingwithsimianvirus40capsidproteinmimotopesinserumsamplesfrompatientsaffectedbyuvealmelanoma

Ejemplares similares