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Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia

BACKGROUND: Mercaptopurine (6-MP) plays a pivotal role in treatment of childhood acute lymphoblastic leukemia (ALL); however, interindividual variability in toxicity of this drug due to genetic polymorphism in 6-MP metabolizing enzymes has been described. We determined the prevalence of the major ge...

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Detalles Bibliográficos
Autores principales:	Farfan, Mauricio J, Salas, Carolina, Canales, Cristina, Silva, Felipe, Villarroel, Milena, Kopp, Katherine, Torres, Juan P, Santolaya, María E, Morales, Jorge
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012712/ https://www.ncbi.nlm.nih.gov/pubmed/24774509 http://dx.doi.org/10.1186/1471-2407-14-299

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