Latest progress in tyrosine kinase inhibitors

Here we discuss the latest progress in development of some kinase inhibitors such as inhibitors of c-MET, LIM and Bcr-Abl kinases. Importantly, many oncogenic kinases signal via the mTOR pathway, suggesting a common target for drug combinations.

Detalles Bibliográficos
Autores principales: Pospelova, Tatiana V., Pospelov, Valery A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012733/
https://www.ncbi.nlm.nih.gov/pubmed/24727648
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author Pospelova, Tatiana V.
Pospelov, Valery A.
author_facet Pospelova, Tatiana V.
Pospelov, Valery A.
author_sort Pospelova, Tatiana V.
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description Here we discuss the latest progress in development of some kinase inhibitors such as inhibitors of c-MET, LIM and Bcr-Abl kinases. Importantly, many oncogenic kinases signal via the mTOR pathway, suggesting a common target for drug combinations.
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spelling pubmed-40127332014-05-09 Latest progress in tyrosine kinase inhibitors Pospelova, Tatiana V. Pospelov, Valery A. Oncotarget Research Perspective Here we discuss the latest progress in development of some kinase inhibitors such as inhibitors of c-MET, LIM and Bcr-Abl kinases. Importantly, many oncogenic kinases signal via the mTOR pathway, suggesting a common target for drug combinations. Impact Journals LLC 2014-03-20 /pmc/articles/PMC4012733/ /pubmed/24727648 Text en Copyright: © 2014 Pospelova and Pospelov. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Perspective
Pospelova, Tatiana V.
Pospelov, Valery A.
Latest progress in tyrosine kinase inhibitors
title Latest progress in tyrosine kinase inhibitors
title_full Latest progress in tyrosine kinase inhibitors
title_fullStr Latest progress in tyrosine kinase inhibitors
title_full_unstemmed Latest progress in tyrosine kinase inhibitors
title_short Latest progress in tyrosine kinase inhibitors
title_sort latest progress in tyrosine kinase inhibitors
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012733/
https://www.ncbi.nlm.nih.gov/pubmed/24727648
work_keys_str_mv AT pospelovatatianav latestprogressintyrosinekinaseinhibitors
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