Persistence and Complex Evolution of Fluoroquinolone-Resistant Streptococcus pneumoniae Clone

Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006–2011 in a post–acute care facility in Israel, despite mandatory vaccination and fluoroquinolone r...

Descripción completa

Detalles Bibliográficos
Autores principales: Ben-David, Debby, Schwaber, Mitchell J., Adler, Amos, Masarwa, Samira, Edgar, Rotem, Navon-Venezia, Shiri, Schwartz, David, Porat, Nurith, Kotlovsky, Tali, Polivkin, Nikolay, Weinberg, Irina, Lazary, Avraham, Ohana, Nissim, Dagan, Ron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012785/
https://www.ncbi.nlm.nih.gov/pubmed/24751142
http://dx.doi.org/10.3201/eid2005.130142
Descripción
Sumario:Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006–2011 in a post–acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone-resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.

Ejemplares similares