Persistence and Complex Evolution of Fluoroquinolone-Resistant Streptococcus pneumoniae Clone

Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006–2011 in a post–acute care facility in Israel, despite mandatory vaccination and fluoroquinolone r...

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Autores principales: Ben-David, Debby, Schwaber, Mitchell J., Adler, Amos, Masarwa, Samira, Edgar, Rotem, Navon-Venezia, Shiri, Schwartz, David, Porat, Nurith, Kotlovsky, Tali, Polivkin, Nikolay, Weinberg, Irina, Lazary, Avraham, Ohana, Nissim, Dagan, Ron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012785/
https://www.ncbi.nlm.nih.gov/pubmed/24751142
http://dx.doi.org/10.3201/eid2005.130142
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author Ben-David, Debby
Schwaber, Mitchell J.
Adler, Amos
Masarwa, Samira
Edgar, Rotem
Navon-Venezia, Shiri
Schwartz, David
Porat, Nurith
Kotlovsky, Tali
Polivkin, Nikolay
Weinberg, Irina
Lazary, Avraham
Ohana, Nissim
Dagan, Ron
author_facet Ben-David, Debby
Schwaber, Mitchell J.
Adler, Amos
Masarwa, Samira
Edgar, Rotem
Navon-Venezia, Shiri
Schwartz, David
Porat, Nurith
Kotlovsky, Tali
Polivkin, Nikolay
Weinberg, Irina
Lazary, Avraham
Ohana, Nissim
Dagan, Ron
author_sort Ben-David, Debby
collection PubMed
description Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006–2011 in a post–acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone-resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.
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spelling pubmed-40127852014-05-09 Persistence and Complex Evolution of Fluoroquinolone-Resistant Streptococcus pneumoniae Clone Ben-David, Debby Schwaber, Mitchell J. Adler, Amos Masarwa, Samira Edgar, Rotem Navon-Venezia, Shiri Schwartz, David Porat, Nurith Kotlovsky, Tali Polivkin, Nikolay Weinberg, Irina Lazary, Avraham Ohana, Nissim Dagan, Ron Emerg Infect Dis Research Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006–2011 in a post–acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone-resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci. Centers for Disease Control and Prevention 2014-05 /pmc/articles/PMC4012785/ /pubmed/24751142 http://dx.doi.org/10.3201/eid2005.130142 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Ben-David, Debby
Schwaber, Mitchell J.
Adler, Amos
Masarwa, Samira
Edgar, Rotem
Navon-Venezia, Shiri
Schwartz, David
Porat, Nurith
Kotlovsky, Tali
Polivkin, Nikolay
Weinberg, Irina
Lazary, Avraham
Ohana, Nissim
Dagan, Ron
Persistence and Complex Evolution of Fluoroquinolone-Resistant Streptococcus pneumoniae Clone
title Persistence and Complex Evolution of Fluoroquinolone-Resistant Streptococcus pneumoniae Clone
title_full Persistence and Complex Evolution of Fluoroquinolone-Resistant Streptococcus pneumoniae Clone
title_fullStr Persistence and Complex Evolution of Fluoroquinolone-Resistant Streptococcus pneumoniae Clone
title_full_unstemmed Persistence and Complex Evolution of Fluoroquinolone-Resistant Streptococcus pneumoniae Clone
title_short Persistence and Complex Evolution of Fluoroquinolone-Resistant Streptococcus pneumoniae Clone
title_sort persistence and complex evolution of fluoroquinolone-resistant streptococcus pneumoniae clone
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012785/
https://www.ncbi.nlm.nih.gov/pubmed/24751142
http://dx.doi.org/10.3201/eid2005.130142
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