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Carriage Rate and Effects of Vaccination after Outbreaks of Serogroup C Meningococcal Disease, Brazil, 2010
During 2010, outbreaks of serogroup C meningococcal (MenC) disease occurred in 2 oil refineries in São Paulo State, Brazil, leading to mass vaccination of employees at 1 refinery with a meningococcal polysaccharide A/C vaccine. A cross-sectional study was conducted to assess the prevalence of mening...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012795/ https://www.ncbi.nlm.nih.gov/pubmed/24751156 http://dx.doi.org/10.3201/eid2005.130948 |
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author | Sáfadi, Marco Aurelio Palazzi Carvalhanas, Telma Regina Marques Pinto Paula de Lemos, Ana Gorla, Maria Cecilia Outeiro Salgado, Maristela Fukasawa, Lucila O. Gonçalves, Maria Gisele Higa, Fabio Brandileone, Maria Cristina Cunto Sacchi, Claudio Tavares Ribeiro, Ana Freitas Sato, Helena Keico Bricks, Lucia Ferro Cassio de Moraes, José |
author_facet | Sáfadi, Marco Aurelio Palazzi Carvalhanas, Telma Regina Marques Pinto Paula de Lemos, Ana Gorla, Maria Cecilia Outeiro Salgado, Maristela Fukasawa, Lucila O. Gonçalves, Maria Gisele Higa, Fabio Brandileone, Maria Cristina Cunto Sacchi, Claudio Tavares Ribeiro, Ana Freitas Sato, Helena Keico Bricks, Lucia Ferro Cassio de Moraes, José |
author_sort | Sáfadi, Marco Aurelio Palazzi |
collection | PubMed |
description | During 2010, outbreaks of serogroup C meningococcal (MenC) disease occurred in 2 oil refineries in São Paulo State, Brazil, leading to mass vaccination of employees at 1 refinery with a meningococcal polysaccharide A/C vaccine. A cross-sectional study was conducted to assess the prevalence of meningococci carriage among workers at both refineries and to investigate the effect of vaccination on and the risk factors for pharyngeal carriage of meningococci. Among the vaccinated and nonvaccinated workers, rates of overall meningococci carriage (21.4% and 21.6%, respectively) and of MenC carriage (6.3% and 4.9%, respectively) were similar. However, a MenC strain belonging to the sequence type103 complex predominated and was responsible for the increased incidence of meningococcal disease in Brazil. A low education level was associated with higher risk of meningococci carriage. Polysaccharide vaccination did not affect carriage or interrupt transmission of the epidemic strain. These findings will help inform future vaccination strategies. |
format | Online Article Text |
id | pubmed-4012795 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-40127952014-05-09 Carriage Rate and Effects of Vaccination after Outbreaks of Serogroup C Meningococcal Disease, Brazil, 2010 Sáfadi, Marco Aurelio Palazzi Carvalhanas, Telma Regina Marques Pinto Paula de Lemos, Ana Gorla, Maria Cecilia Outeiro Salgado, Maristela Fukasawa, Lucila O. Gonçalves, Maria Gisele Higa, Fabio Brandileone, Maria Cristina Cunto Sacchi, Claudio Tavares Ribeiro, Ana Freitas Sato, Helena Keico Bricks, Lucia Ferro Cassio de Moraes, José Emerg Infect Dis Research During 2010, outbreaks of serogroup C meningococcal (MenC) disease occurred in 2 oil refineries in São Paulo State, Brazil, leading to mass vaccination of employees at 1 refinery with a meningococcal polysaccharide A/C vaccine. A cross-sectional study was conducted to assess the prevalence of meningococci carriage among workers at both refineries and to investigate the effect of vaccination on and the risk factors for pharyngeal carriage of meningococci. Among the vaccinated and nonvaccinated workers, rates of overall meningococci carriage (21.4% and 21.6%, respectively) and of MenC carriage (6.3% and 4.9%, respectively) were similar. However, a MenC strain belonging to the sequence type103 complex predominated and was responsible for the increased incidence of meningococcal disease in Brazil. A low education level was associated with higher risk of meningococci carriage. Polysaccharide vaccination did not affect carriage or interrupt transmission of the epidemic strain. These findings will help inform future vaccination strategies. Centers for Disease Control and Prevention 2014-05 /pmc/articles/PMC4012795/ /pubmed/24751156 http://dx.doi.org/10.3201/eid2005.130948 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Sáfadi, Marco Aurelio Palazzi Carvalhanas, Telma Regina Marques Pinto Paula de Lemos, Ana Gorla, Maria Cecilia Outeiro Salgado, Maristela Fukasawa, Lucila O. Gonçalves, Maria Gisele Higa, Fabio Brandileone, Maria Cristina Cunto Sacchi, Claudio Tavares Ribeiro, Ana Freitas Sato, Helena Keico Bricks, Lucia Ferro Cassio de Moraes, José Carriage Rate and Effects of Vaccination after Outbreaks of Serogroup C Meningococcal Disease, Brazil, 2010 |
title | Carriage Rate and Effects of Vaccination after Outbreaks of Serogroup C Meningococcal Disease, Brazil, 2010 |
title_full | Carriage Rate and Effects of Vaccination after Outbreaks of Serogroup C Meningococcal Disease, Brazil, 2010 |
title_fullStr | Carriage Rate and Effects of Vaccination after Outbreaks of Serogroup C Meningococcal Disease, Brazil, 2010 |
title_full_unstemmed | Carriage Rate and Effects of Vaccination after Outbreaks of Serogroup C Meningococcal Disease, Brazil, 2010 |
title_short | Carriage Rate and Effects of Vaccination after Outbreaks of Serogroup C Meningococcal Disease, Brazil, 2010 |
title_sort | carriage rate and effects of vaccination after outbreaks of serogroup c meningococcal disease, brazil, 2010 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012795/ https://www.ncbi.nlm.nih.gov/pubmed/24751156 http://dx.doi.org/10.3201/eid2005.130948 |
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