MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways

The mechanisms underlying the development of aging-induced muscle atrophy are unclear. By microRNA array and individual qPCR analyses, we found significant up-regulation of miR-29 in muscles of aged rodents vs. results in young. With aging, p85α, IGF-1 and B-myb muscle levels were lower while the ex...

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Detalles Bibliográficos
Autores principales: Hu, Zhaoyong, Klein, Janet D., Mitch, William E., Zhang, Liping, Martinez, Ivan, Wang, Xiaonan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012934/
https://www.ncbi.nlm.nih.gov/pubmed/24659628

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