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Metabolic profiles of biological aging in American Indians: The strong heart family study

Short telomere length, a marker of biological aging, has been associated with age-related metabolic disorders. Telomere attrition induces profound metabolic dysfunction in animal models, but no study has examined the metabolome of telomeric aging in human. Here we studied 423 apparently healthy Amer...

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Autores principales: Zhao, Jinying, Zhu, Yun, Uppal, Karan, Tran, ViLinh T., Yu, Tianwei, Lin, Jue, Matsuguchi, Tet, Blackburn, Elizabeth, Jones, Dean, Lee, Elisa T., Howard, Barbara V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012935/
https://www.ncbi.nlm.nih.gov/pubmed/24799415
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author Zhao, Jinying
Zhu, Yun
Uppal, Karan
Tran, ViLinh T.
Yu, Tianwei
Lin, Jue
Matsuguchi, Tet
Blackburn, Elizabeth
Jones, Dean
Lee, Elisa T.
Howard, Barbara V.
author_facet Zhao, Jinying
Zhu, Yun
Uppal, Karan
Tran, ViLinh T.
Yu, Tianwei
Lin, Jue
Matsuguchi, Tet
Blackburn, Elizabeth
Jones, Dean
Lee, Elisa T.
Howard, Barbara V.
author_sort Zhao, Jinying
collection PubMed
description Short telomere length, a marker of biological aging, has been associated with age-related metabolic disorders. Telomere attrition induces profound metabolic dysfunction in animal models, but no study has examined the metabolome of telomeric aging in human. Here we studied 423 apparently healthy American Indians participating in the Strong Family Heart Study. Leukocyte telomere length (LTL) was measured by qPCR. Metabolites in fasting plasma were detected by untargeted LC/MS. Associations of LTL with each metabolite and their combined effects were examined using generalized estimating equation adjusting for chronological age and other aging-related factors. Multiple testing was corrected using the q-value method (q<0.05). Of the 1,364 distinct m/z features detected, nineteen metabolites in the classes of glycerophosphoethanolamines, glycerophosphocholines, glycerolipids, bile acids, isoprenoids, fatty amides, or L-carnitine ester were significantly associated with LTL, independent of chronological age and other aging-related factors. Participants with longer (top tertile) and shorter (bottom tertile) LTL were clearly separated into distinct groups using a multi-marker score comprising of all these metabolites, suggesting that these newly detected metabolites could be novel metabolic markers of biological aging. This is the first study to interrogate the human metabolome of telomeric aging. Our results provide initial evidence for a metabolic control of LTL and may reveal previously undescribed new roles of various lipids in the aging process.
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spelling pubmed-40129352014-05-09 Metabolic profiles of biological aging in American Indians: The strong heart family study Zhao, Jinying Zhu, Yun Uppal, Karan Tran, ViLinh T. Yu, Tianwei Lin, Jue Matsuguchi, Tet Blackburn, Elizabeth Jones, Dean Lee, Elisa T. Howard, Barbara V. Aging (Albany NY) Research Paper Short telomere length, a marker of biological aging, has been associated with age-related metabolic disorders. Telomere attrition induces profound metabolic dysfunction in animal models, but no study has examined the metabolome of telomeric aging in human. Here we studied 423 apparently healthy American Indians participating in the Strong Family Heart Study. Leukocyte telomere length (LTL) was measured by qPCR. Metabolites in fasting plasma were detected by untargeted LC/MS. Associations of LTL with each metabolite and their combined effects were examined using generalized estimating equation adjusting for chronological age and other aging-related factors. Multiple testing was corrected using the q-value method (q<0.05). Of the 1,364 distinct m/z features detected, nineteen metabolites in the classes of glycerophosphoethanolamines, glycerophosphocholines, glycerolipids, bile acids, isoprenoids, fatty amides, or L-carnitine ester were significantly associated with LTL, independent of chronological age and other aging-related factors. Participants with longer (top tertile) and shorter (bottom tertile) LTL were clearly separated into distinct groups using a multi-marker score comprising of all these metabolites, suggesting that these newly detected metabolites could be novel metabolic markers of biological aging. This is the first study to interrogate the human metabolome of telomeric aging. Our results provide initial evidence for a metabolic control of LTL and may reveal previously undescribed new roles of various lipids in the aging process. Impact Journals LLC 2014-03-20 /pmc/articles/PMC4012935/ /pubmed/24799415 Text en Copyright: © 2014 Zhao et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Paper
Zhao, Jinying
Zhu, Yun
Uppal, Karan
Tran, ViLinh T.
Yu, Tianwei
Lin, Jue
Matsuguchi, Tet
Blackburn, Elizabeth
Jones, Dean
Lee, Elisa T.
Howard, Barbara V.
Metabolic profiles of biological aging in American Indians: The strong heart family study
title Metabolic profiles of biological aging in American Indians: The strong heart family study
title_full Metabolic profiles of biological aging in American Indians: The strong heart family study
title_fullStr Metabolic profiles of biological aging in American Indians: The strong heart family study
title_full_unstemmed Metabolic profiles of biological aging in American Indians: The strong heart family study
title_short Metabolic profiles of biological aging in American Indians: The strong heart family study
title_sort metabolic profiles of biological aging in american indians: the strong heart family study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012935/
https://www.ncbi.nlm.nih.gov/pubmed/24799415
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