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Hexosamine pathway but not interstitial changes mediates glucotoxicity in pancreatic β-cells as assessed by cytosolic Ca(2+) response to glucose

Hyperglycemia impairs insulin secretion as well as insulin action, being recognized as the glucotoxicity that accelerates diabetes. However, the mechanism underlying the glucotoxicity in pancreatic β-cells is not thoroughly understood. Hyperglycemia alters glucose metabolism within β-cells and inter...

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Detalles Bibliográficos
Autores principales:	Yanagida, Kazuhiro, Maejima, Yuko, Santoso, Putra, Otgon-Uul, Zesemdorj, Yang, Yifei, Sakuma, Kazuya, Shimomura, Kenju, Yada, Toshihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012937/ https://www.ncbi.nlm.nih.gov/pubmed/24704640

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