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Epidemiology of Acute Pancreatitis in Hospitalized Children in the United States from 2000–2009
BACKGROUND: Single-center studies suggest an increasing incidence of acute pancreatitis (AP) in children. Our specific aims were to (i) estimate the recent secular trends, (ii) assess the disease burden, and (iii) define the demographics and comorbid conditions of AP in hospitalized children within...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012949/ https://www.ncbi.nlm.nih.gov/pubmed/24805879 http://dx.doi.org/10.1371/journal.pone.0095552 |
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author | Pant, Chaitanya Deshpande, Abhishek Olyaee, Mojtaba Anderson, Michael P. Bitar, Anas Steele, Marilyn I. Bass, Pat F. Sferra, Thomas J. |
author_facet | Pant, Chaitanya Deshpande, Abhishek Olyaee, Mojtaba Anderson, Michael P. Bitar, Anas Steele, Marilyn I. Bass, Pat F. Sferra, Thomas J. |
author_sort | Pant, Chaitanya |
collection | PubMed |
description | BACKGROUND: Single-center studies suggest an increasing incidence of acute pancreatitis (AP) in children. Our specific aims were to (i) estimate the recent secular trends, (ii) assess the disease burden, and (iii) define the demographics and comorbid conditions of AP in hospitalized children within the United States. METHODS: We used the Healthcare Cost and Utilization Project Kids’ Inpatient Database, Agency for Healthcare Research and Quality for the years 2000 to 2009. Extracted data were weighted to generate national-level estimates. We used the Cochrane-Armitage test to analyze trends; cohort-matching to evaluate the association of AP and in-hospital mortality, length of stay, and charges; and multivariable logistic regression to test the association of AP and demographics and comorbid conditions. RESULTS: We identified 55,012 cases of AP in hospitalized children (1–20 years of age). The incidence of AP increased from 23.1 to 34.9 (cases per 10,000 hospitalizations per year; P<0.001) and for all-diagnoses 38.7 to 61.1 (P<0.001). There was an increasing trend in the incidence of both primary and all-diagnoses of AP (P<0.001). In-hospital mortality decreased (13.1 to 7.6 per 1,000 cases, P<0.001), median length of stay decreased (5 to 4 days, P<0.001), and median charges increased ($14,956 to $22,663, P<0.001). Children with AP compared to those without the disease had lower in-hospital mortality (adjusted odds ratio, aOR 0.86, 95% CI, 0.78–0.95), longer lengths of stay (aOR 2.42, 95% CI, 2.40–2.46), and higher charges (aOR 1.62, 95% CI, 1.59–1.65). AP was more likely to occur in children older than 5 years of age (aORs 2.81 to 5.25 for each 5-year age interval). Hepatobiliary disease was the comorbid condition with the greatest association with AP. CONCLUSIONS: These results demonstrate a rising incidence of AP in hospitalized children. Despite improvements in mortality and length of stay, hospitalized children with AP have significant morbidity. |
format | Online Article Text |
id | pubmed-4012949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40129492014-05-09 Epidemiology of Acute Pancreatitis in Hospitalized Children in the United States from 2000–2009 Pant, Chaitanya Deshpande, Abhishek Olyaee, Mojtaba Anderson, Michael P. Bitar, Anas Steele, Marilyn I. Bass, Pat F. Sferra, Thomas J. PLoS One Research Article BACKGROUND: Single-center studies suggest an increasing incidence of acute pancreatitis (AP) in children. Our specific aims were to (i) estimate the recent secular trends, (ii) assess the disease burden, and (iii) define the demographics and comorbid conditions of AP in hospitalized children within the United States. METHODS: We used the Healthcare Cost and Utilization Project Kids’ Inpatient Database, Agency for Healthcare Research and Quality for the years 2000 to 2009. Extracted data were weighted to generate national-level estimates. We used the Cochrane-Armitage test to analyze trends; cohort-matching to evaluate the association of AP and in-hospital mortality, length of stay, and charges; and multivariable logistic regression to test the association of AP and demographics and comorbid conditions. RESULTS: We identified 55,012 cases of AP in hospitalized children (1–20 years of age). The incidence of AP increased from 23.1 to 34.9 (cases per 10,000 hospitalizations per year; P<0.001) and for all-diagnoses 38.7 to 61.1 (P<0.001). There was an increasing trend in the incidence of both primary and all-diagnoses of AP (P<0.001). In-hospital mortality decreased (13.1 to 7.6 per 1,000 cases, P<0.001), median length of stay decreased (5 to 4 days, P<0.001), and median charges increased ($14,956 to $22,663, P<0.001). Children with AP compared to those without the disease had lower in-hospital mortality (adjusted odds ratio, aOR 0.86, 95% CI, 0.78–0.95), longer lengths of stay (aOR 2.42, 95% CI, 2.40–2.46), and higher charges (aOR 1.62, 95% CI, 1.59–1.65). AP was more likely to occur in children older than 5 years of age (aORs 2.81 to 5.25 for each 5-year age interval). Hepatobiliary disease was the comorbid condition with the greatest association with AP. CONCLUSIONS: These results demonstrate a rising incidence of AP in hospitalized children. Despite improvements in mortality and length of stay, hospitalized children with AP have significant morbidity. Public Library of Science 2014-05-07 /pmc/articles/PMC4012949/ /pubmed/24805879 http://dx.doi.org/10.1371/journal.pone.0095552 Text en © 2014 Pant et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Pant, Chaitanya Deshpande, Abhishek Olyaee, Mojtaba Anderson, Michael P. Bitar, Anas Steele, Marilyn I. Bass, Pat F. Sferra, Thomas J. Epidemiology of Acute Pancreatitis in Hospitalized Children in the United States from 2000–2009 |
title | Epidemiology of Acute Pancreatitis in Hospitalized Children in the United States from 2000–2009 |
title_full | Epidemiology of Acute Pancreatitis in Hospitalized Children in the United States from 2000–2009 |
title_fullStr | Epidemiology of Acute Pancreatitis in Hospitalized Children in the United States from 2000–2009 |
title_full_unstemmed | Epidemiology of Acute Pancreatitis in Hospitalized Children in the United States from 2000–2009 |
title_short | Epidemiology of Acute Pancreatitis in Hospitalized Children in the United States from 2000–2009 |
title_sort | epidemiology of acute pancreatitis in hospitalized children in the united states from 2000–2009 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012949/ https://www.ncbi.nlm.nih.gov/pubmed/24805879 http://dx.doi.org/10.1371/journal.pone.0095552 |
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