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A Visual ERP Study of Impulse Inhibition following a Zaleplon-Induced Nap after Sleep Deprivation
The side effects of a zaleplon-induced nap as a countermeasure in the reduction of impulse inhibition function decline following 30 h of sleep deprivation (SD) were examined by event-related brain potentials. Sixteen adult participants performed a Go/NoGo task at five time points: (1) baseline; (2)...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012989/ https://www.ncbi.nlm.nih.gov/pubmed/24806263 http://dx.doi.org/10.1371/journal.pone.0095653 |
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author | Zhang, Qianru Liao, Yang Qi, Jianlin Zhao, Yongqi Zhu, Tianli Liu, Zhaohui Liu, Xufeng |
author_facet | Zhang, Qianru Liao, Yang Qi, Jianlin Zhao, Yongqi Zhu, Tianli Liu, Zhaohui Liu, Xufeng |
author_sort | Zhang, Qianru |
collection | PubMed |
description | The side effects of a zaleplon-induced nap as a countermeasure in the reduction of impulse inhibition function decline following 30 h of sleep deprivation (SD) were examined by event-related brain potentials. Sixteen adult participants performed a Go/NoGo task at five time points: (1) baseline; (2) after 30 h of SD; (3) upon sudden awakening, also called 2 h post-drug; (4) 4 h post-drug; and (5) 6 h post-drug. Behavior results show an increase in both reaction time and false alarm rates after SD and sudden awakening, and a marked decrease at 4 h and 6 h post-drug in zaleplon and placebo conditions. However, no difference was observed between the zaleplon condition and the placebo condition. In event-related potential (ERP) reults compared with results obtained under control conditions, NoGo-P3 latencies significantly increased, whereas the Nogo-P3 amplitude decreased after 30 h of SD and sudden awakening in both the zaleplon condition and the placebo condition. These results indicate that SD attenuates resource allocation and error monitoring for NoGo stimuli. In addition, NoGo-P3 latencies were longer in the zaleplon condition compared with the placebo condition at sudden awakening. Additionally, the NoGo-P3 latencies were shorter in the zaleplon condition than in the placebo condition at 4 h and 6 h post-drug. These results indicate that zaleplon at a dose of 10 mg/day may help subjects achieve a better recovery or maintain better impulse inhibition function, although the side effects of zaleplon last at least 2 h post-drug. |
format | Online Article Text |
id | pubmed-4012989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40129892014-05-09 A Visual ERP Study of Impulse Inhibition following a Zaleplon-Induced Nap after Sleep Deprivation Zhang, Qianru Liao, Yang Qi, Jianlin Zhao, Yongqi Zhu, Tianli Liu, Zhaohui Liu, Xufeng PLoS One Research Article The side effects of a zaleplon-induced nap as a countermeasure in the reduction of impulse inhibition function decline following 30 h of sleep deprivation (SD) were examined by event-related brain potentials. Sixteen adult participants performed a Go/NoGo task at five time points: (1) baseline; (2) after 30 h of SD; (3) upon sudden awakening, also called 2 h post-drug; (4) 4 h post-drug; and (5) 6 h post-drug. Behavior results show an increase in both reaction time and false alarm rates after SD and sudden awakening, and a marked decrease at 4 h and 6 h post-drug in zaleplon and placebo conditions. However, no difference was observed between the zaleplon condition and the placebo condition. In event-related potential (ERP) reults compared with results obtained under control conditions, NoGo-P3 latencies significantly increased, whereas the Nogo-P3 amplitude decreased after 30 h of SD and sudden awakening in both the zaleplon condition and the placebo condition. These results indicate that SD attenuates resource allocation and error monitoring for NoGo stimuli. In addition, NoGo-P3 latencies were longer in the zaleplon condition compared with the placebo condition at sudden awakening. Additionally, the NoGo-P3 latencies were shorter in the zaleplon condition than in the placebo condition at 4 h and 6 h post-drug. These results indicate that zaleplon at a dose of 10 mg/day may help subjects achieve a better recovery or maintain better impulse inhibition function, although the side effects of zaleplon last at least 2 h post-drug. Public Library of Science 2014-05-07 /pmc/articles/PMC4012989/ /pubmed/24806263 http://dx.doi.org/10.1371/journal.pone.0095653 Text en © 2014 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zhang, Qianru Liao, Yang Qi, Jianlin Zhao, Yongqi Zhu, Tianli Liu, Zhaohui Liu, Xufeng A Visual ERP Study of Impulse Inhibition following a Zaleplon-Induced Nap after Sleep Deprivation |
title | A Visual ERP Study of Impulse Inhibition following a Zaleplon-Induced Nap after Sleep Deprivation |
title_full | A Visual ERP Study of Impulse Inhibition following a Zaleplon-Induced Nap after Sleep Deprivation |
title_fullStr | A Visual ERP Study of Impulse Inhibition following a Zaleplon-Induced Nap after Sleep Deprivation |
title_full_unstemmed | A Visual ERP Study of Impulse Inhibition following a Zaleplon-Induced Nap after Sleep Deprivation |
title_short | A Visual ERP Study of Impulse Inhibition following a Zaleplon-Induced Nap after Sleep Deprivation |
title_sort | visual erp study of impulse inhibition following a zaleplon-induced nap after sleep deprivation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012989/ https://www.ncbi.nlm.nih.gov/pubmed/24806263 http://dx.doi.org/10.1371/journal.pone.0095653 |
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